Results 31 to 40 of about 382,242 (307)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Seasonal Variation in Hip Fracture Mortality

Geriatric Orthopaedic Surgery & Rehabilitation, 2017
Objectives: This study aims to identify if wintertime surgery increases the mortality of the patients after hip fracture operations. Design: Retrospective observational cohort study.
Dennis K. H. Yee MBBS, FRCS, FHKAM, Christian Fang MBBS, FRCS, FHKAM, T. W. Lau MBBS, FRCS, FHKAM, Terence Pun MBBS, FRCS, FHKAM, T. M. Wong MBBS, FRCS, FHKAM, Frankie Leung MBBS, FRCS, FHKAM   +5 more
doaj   +1 more source

LAMs and the participatory turn

, 2022
The entire cultural field is witnessing a “participatory turn,” and among LAMs, participation has been the most prominent buzzword for more than a decade. This chapter describes and discusses different types of participation, including crowdsourcing, co-creation, and the facilitation of shared experiences of culture and art.
Huvila, Isto, Johnston, Jamie, Roued-Cunliffe, Henriette   +2 more
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Lateral-flow urine lipoarabinomannan for TB diagnosis in children

IJTLD Open
BACKGROUND: Diagnosing childhood TB is challenging due to nonspecific symptoms and difficulty obtaining sputum samples. This study evaluated the urine-based Alere Determine™ TB-LAM Ag test (AlereLAM) in a high-burden TB, HIV, and malnutrition setting ...
R. Mahajan, L.F. Nyikayo, Y.B. Peter Ajack, B.T. Chol, M. Sangma, J. Ayor, M.J. Sagrado, A.E. Llosa, L. Moretó-Planas   +8 more
doaj   +1 more source

Clinical outcomes in LAM and LAM+ADV groups.

, 2016
Clinical outcomes in LAM and LAM+ADV groups.
Huiqiang Huang (419481), Huaxin Duan (3202527), Liyang Hu (3202536), Wenqi Jiang (1638793), Mengfei Yao (3202524), Zhongjun Xia (3202539), Tongyu Lin (419484), Qirong Geng (318876), Huilan Rao (3202530), Shaoxu Wu (3202533), Qingqing Cai (317710), Jie Chen (5892), Kailin Chen (419483)   +12 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Lymphangioleiomyomatosis Patient Research Priorities Survey (LAM-PREP)Take-Home Points

CHEST Pulmonary
Background: Engaging patients in developing research agendas is recognized as critical in advancing scientific discovery and improving clinical care.
Marina K. Holz, PhD, DrPH, Andrea D. Slattery, BSBA, Eden J. Pontz, BA, Stephanie R. Dreyer, MBA, Gregory P. Downey, MD, Nishant Gupta, MD, MS, Susan E. Sherman, MHA, Vera P. Krymskaya, PhD, Lyndsay M. Hoy, MD   +8 more
doaj   +1 more source

Una procedura numerica per il calcolo di edifici in X-Lam

, 2022
L’obiettivo di questo lavoro è la definizione, l’implementazione ed una prima validazione di una procedura per il progetto e la verifica di edifici in legno con struttura portante in pannelli X–Lam.
Zecchetto, Massimiliano
core