Results 81 to 90 of about 382,242 (307)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Identifying orchid hotspots for biodiversity conservation in Laos: the limestone karst vegetation of Vang Vieng District, Vientiane Province

Journal of Threatened Taxa, 2016
A project to study the phytodiversity of the Indo-Burma Biodiversity Hotspot (IBBH) was initiated by Kadoorie Farm and Botanic Garden, Hong Kong, in 2011, with the aim of surveying primary forest fragments and identifying conservation priorities within ...
Pankaj Kumar, Stephan W. Gale, André Schuiteman, Somsanith Bouamanivong, Gunter A. Fischer   +4 more
doaj   +1 more source

DIY: Zine-Making in LAMS, for LAMS

Zines are easy and affordable to make and distribute. While there has been scholarship on acquiring and preserving zines in Libraries, Archives, and Museums (LAMS), less has been studied about LAMS workers making zines in these contexts. With a return to campus after the COVID-19 pandemic, zines proved to be a fun way to engage and inform patrons about
Hurst, Emma Metcalfe, Taichman, Marsha
openaire   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Apical shoot propagation of Taxus wallichiana Zucc. in Vietnam: a conservation-oriented approach to overcome the limitations of lateral cuttings

Folia Oecologica
Taxus wallichiana Zucc. is an endangered medicinal tree species valued for its production of paclitaxel, but its conservation is constrained by overexploitation and poor natural regeneration.
Phuc Nguyen Van, Cam Ngo Van, Doan Nguyen Pham, Hung Ho Si, Hoa Le Thi Thuy, Cuong Truong Quang, Son Le Van, Van Dang Van, Khanh Pham Tran Thi Van, En Le Hong   +9 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Slow focus sensor for the Keck I laser guide star adaptive optics system using focal plane wavefront sensing

Astronomy & Astrophysics
Context. Laser guide stars (LGSs) have been deployed for the last 20–30 years in ground-based astronomical telescopes to overcome the limited sky coverage of classical adaptive optics (AO) systems.
Salgueiro Rafael M., Correia Carlos M., Neichel Benoit, Bouchez Antonin, Wizinowich Peter, Surendran Avinash, Service Max, Fusco Thierry, Héritier Cédric Taïssir, Jouve Pierre   +9 more
doaj   +1 more source

Lymphangioleiomyomatosis (LAM) [PDF]

American Journal of Respiratory and Critical Care Medicine, 2018
Ali, Ataya, Mark, Brantly, Leonard, Riley   +2 more
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Constellation du Sud. Some notes upon Wifredo Lam and the avant-garde in Italy: Lucio Fontana, Asger Jorn, Piero Manzoni

, 2018
Analisi storico-artistica del rapporto di Lam con il contesto internazionale della Albisola degli anni ...
L. Bochicchio
core   +1 more source