Results 61 to 70 of about 382,242 (307)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Kinematics of the H II region NGC 7538 from study of the Hα line

Astronomy & Astrophysics
Aims. Massive stars impact their surroundings, triggering star formation at their edges. Once the H II region is formed, it is unclear if and how the second generation of stars impacts its aspect and evolution. Methods.
Russeil D., Plana H., Amram P., Zavagno A., Michel F.   +4 more
doaj   +1 more source

Oral History of Charlie Lam

, 2019
An oral history with Charlie Lam, born in 1960 in rural Cambodia, near Sihanoukville. He is a 2nd generation ethnic Chinese, where his grandparents migrated to Cambodia from Hainan, China. When he was 12, he and his family migrated to Kien Giang, Vietnam
Lam, Charlie
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Balancing Economy and Ecology: A System Dynamics Analysis of Shrimp Aquaculture and Mangrove Forest Policy

Journal of Sustainable Development of Energy, Water and Environment Systems
The rapid expansion of shrimp farming in Ca Mau Province, Vietnam since the early 2000s has converted mangrove forests into aquaculture ponds, resulting in deforestation and degraded mangrove ecosystems.
Hoang Ha Anh, Le Cong Tru, Nguyen Van Trai, Tran Minh Da Hanh, Nguyen Van Cuong   +4 more
doaj   +1 more source

Closing the loop on-sky with a vector-Zernike wavefront sensor using a convolutional neural network as a phase reconstructor

Astronomy & Astrophysics
Context. The new giant segmented mirror telescopes will use adaptive optics to reach the fundamental limits in resolving power. To fulfill the requirements to accomplish this, new wavefront sensors (WFS) have been designed, but they may require nonlinear
Oyarzún F., Motte M., Heritier C. T., González B., Muñoz R., Chambouleyron V., Alagao M. A., Striffling A., Pasinetti M., Vinerskas E., Trouve-Peloux P., Champagnat F., Fusco T., Neichel B.   +13 more
doaj   +1 more source

Determine TB-LAM lateral flow urine antigen assay for HIV-associated tuberculosis: recommendations on the design and reporting of clinical studies. [PDF]

, 2013
Detection of the Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (LAM) in urine permits diagnoses of tuberculosis (TB) to be made in HIV-infected patients with advanced immunodeficiency.
Kerkhoff, Andrew D, Dorman, Susan, Peter, Jonathan, Nicol, Mark, Catharina C Boehme, Peter, Jonathan G, Boehme, Catharina C, Kerkhoff, Andrew, Nicol, Mark P, Keertan Dheda, Peter, Jonathan G., Lawn, Stephen, Lawn, Stephen D., Kerkhoff, Andrew D., Lawn, Stephen D, Dheda, Keertan, Mark P Nicol, Andrew D Kerkhoff, Nicol, Mark P., Jonathan G Peter, Boehme, Catharina, Stephen D Lawn, Susan Dorman, Boehme, Catharina C.   +23 more
core   +2 more sources

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Isolation and purification of LAM.

, 2019
Crude LAM (10 mg/ml PBS) was passed through sephacryl S-100 column (equilibrated with PBS) at flow rate of 0.5 ml/min. Fractions of 3 ml each were collected. Carbohydrate content (dotted line, O.D. at 490 nm) and LAM content (Solid line, O.D.
Anush Chakraborty (7542812), Sangeeta Bhaskar (183261), Bindu Singh (4683637), Mohd Saqib (4683631)   +3 more
core   +1 more source