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Lambert-eaton myasthenic syndrome

Current Treatment Options in Neurology, 2009
Lambert Eaton myasthenic syndrome (LEMS) is a rare neuromuscular junction disease. Often, the signs and symptoms of LEMS are mistaken for myasthenia gravis and therefore the workup is misdirected. A physician must look for an occult malignancy when the diagnosis is made and then continue to search for a malignancy for at least 5 years after diagnosis ...
Maria B, Weimer, Joaquin, Wong
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Lambert-Eaton Myasthenic Syndrome

Seminars in Neurology, 2004
Lambert-Eaton myasthenic syndrome (LEMS) is an idiopathic or paraneoplastic syndrome producing antibodies against presynaptic voltage-gated P/Q calcium channels. This decreases calcium entry into the presynaptic terminal, which prevents binding of vesicles to the presynaptic membrane and acetylcholine release.
Michael, Mareska, Laurie, Gutmann
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Lambert-Eaton Myasthenic Syndrome

Revue Neurologique, 1985
The Lambert-Eaton Myasthenic Syndrome (LEMS) is characterised by proximal muscle weakness initially affecting gait, autonomic symptoms (dry mouth, constipation, erectile failure), augmentation of strength during initial voluntary activation, and depressed tendon reflexes with post-tetanic potentiation.
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Lambert–Eaton myasthenic syndrome in childhood

European Journal of Paediatric Neurology, 2009
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder of the neuromuscular junction. LEMS can be associated with a variety of neoplasms. Patients present with proximal muscle weakness and fatigability, often combined with areflexia. Only 5% of reported cases are children.
A, Kostera-Pruszczyk, B, Ryniewicz, K, Rowinska-Marcinska, M, Dutkiewicz, A, Kamińska   +4 more
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Lambert‐Eaton Myasthenic Syndrome

Annals of the New York Academy of Sciences, 2003
Abstract: A high index of suspicion is essential in arriving at the correct diagnosis of Lambert‐Eaton myasthenic syndrome (LEMS). LEMS should be considered in the differential in any patient who has proximal weakness, reduced or absent muscle stretch reflexes, and dry mouth.
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The Lambert-Eaton Myasthenic Syndrome

2013
The Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease of the neuromuscular junction. The main symptom in LEMS is proximal muscle weakness in the legs, which is the presenting symptom in most patients. Autonomic dysfunction is also part of the clinical spectrum.
Wirtz, Paul W., Titulaer, Maarten J., Verschuuren, Jan J.G.M.   +2 more
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Lambert-Eaton Myasthenic Syndrome

2023
Abstract Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder that results in decreased release of acetylcholine at the neuromuscular junction secondary to autoantibodies against calcium channels at the presynaptic nerve terminal.
Sabrina S. Sam, Syena Sarrafpour
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Lambert–Eaton Myasthenic Syndrome

2017
Lambert–Eaton myasthenic syndrome (LEMS) is an uncommon presynaptic disorder of the neuromuscular junction. It presents with progressive proximal weakness, depressed tendon reflexes and autonomic dysfunction. Electrophysiological triad of low amplitude motor potentials, decremental response on low rate repetitive nerve stimulation (RNS) and increment ...
Satish V. Khadilkar, Rakhil S. Yadav, Bhagyadhan A. Patel   +2 more
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[Lambert-Eaton myasthenic syndrome].

Brain and nerve = Shinkei kenkyu no shinpo, 2011
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease of the neuromuscular junction, and approximately 60% of patients with LEMS have a tumor, mostly small cell lung cancer (SCLC), as a paraneoplastic neurological syndrome. The clinical data of Japanese patients in the present study are as follows: the ratio of men to women is 3: 1 (mean ...
Masakatsu, Motomura, Taku, Fukuda
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Lambert–Eaton Myasthenic Syndrome

Journal of Neuro-Ophthalmology, 2016
To evaluate ocular signs and symptoms in Lambert-Eaton myasthenic syndrome (LEMS) and determine the frequency of ophthalmic involvement.A retrospective review of the medical records of all patients diagnosed with LEMS at the Mayo Clinic in Rochester, MN, from January, 1976, to December, 2010, was performed with special attention to ophthalmic symptoms ...
Jeffery D, Young, Jacqueline A, Leavitt
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