Results 81 to 90 of about 6,688 (239)

Voltage-gated sodium channels: new targets in cancer therapy? [PDF]

, 2006
Early detection and treatment of cancers have increased survival and improved clinical outcome. The development of metastases is often associated with a poor prognostic of survival. Finding early markers of metastasis and developing new therapies against
Besson, Pierre, Le Guennec, Jean-Yves, Potier, Marie, Roger, Sébastien, Vandier, Christophe   +4 more
core   +2 more sources

Paraneoplastic neurological syndrome and its impact on the treatment outcomes of small‐cell lung cancer: A single‐center retrospective analysis

Thoracic Cancer, Volume 15, Issue 34, Page 2418-2427, December 2024.
Patients diagnosed with small‐cell lung cancer (SCLC) at a single center between August 2007 and April 2021 were retrospectively analyzed. A total of 318 patients were evaluated; paraneoplastic neurological syndrome (PNS) was present in 2.8% (n = 9) of the overall population.
Yuki Sato, Satoru Fujiwara, Chigusa Shirakawa, Ryosuke Hirabayashi, Kazuma Nagata, Atsushi Nakagawa, Ryo Tachikawa, Keisuke Tomii   +7 more
wiley   +1 more source

Lamber-Eaton myasthenic syndrome associated with multiple myeloma: A case report

Current Problems in Cancer: Case Reports
Background: Lambert-Eaton myasthenic syndrome (LEMS) is an uncommon illness of the neuromuscular junction. It typically manifests as a combination of proximal muscular weakness, autonomic dysfunction, and areflexia.
Sebastian S Casillas-Berumen, Ahsan Salik, Alex Yu, Mageda Al Areqi, Ayesha Ali, Resham Mirza, Shaan Chaudhri, Gurpreet Lamba   +7 more
doaj   +1 more source

Anti-CV2/CRMP5 antibody-positive paraneoplastic neurological syndromes with chronic intestinal pseudo-obstruction in a small-cell lung cancer patient: a case report and literature review

Journal of International Medical Research, 2020
Patients with anti-CV2/collapsin response mediator protein (CRMP)5 antibodies present with more frequent chorea, cerebellar ataxia, uveo/retinal symptoms, and Lambert–Eaton myasthenic syndrome or myasthenia gravis.
Jinhua Yan, Zhongbo Chen, Yumei Liang, Huijia Yang, Lizhi Cao, Yuling Zhou, Yang Zhao, Ying Zhang   +7 more
doaj   +1 more source

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G., Ahnert-Hilger G., Bader M. F., Baumert M., Bittner M. A., Bittner M. A., Bittner M. A., Blasi J., Elferink L. A., Fischer G., Geppert M., Halpern J. L., Hess S. D., Jahn R., MANFRED GRATZL, Marqueze-Pouey B., McMahon H. T., Schiavo G., Schiavo G., Schiavo G., Schmidle T., Shirataki H., Shoji-Kasai Y., Stecher B., Thomas L., Trimble W. S., Walch-Solimena C., Wright J. F., Yoshida A.   +28 more
core   +1 more source

Antibodies against endogenous retroviruses

Immunological Reviews, Volume 328, Issue 1, Page 300-313, November 2024.
Summary The human genome harbors hundreds of thousands of integrations of ancient retroviruses, amassed over millions of years of evolution. To reduce further amplification in the genome, the host prevents transcription of these now endogenous retroviruses (ERVs) through epigenetic repression and, with evolutionary time, ERVs are incapacitated by ...
Mihaela Chisca, Jean‐David Larouche, Qi Xing, George Kassiotis   +3 more
wiley   +1 more source

The impact of diagnosis delay on European patients with generalised myasthenia gravis

Annals of Clinical and Translational Neurology, Volume 11, Issue 9, Page 2254-2267, September 2024.
Abstract Objective The objective was to determine the mean duration of diagnosis delay for patients with myasthenia gravis from five European countries and explore the impact of >1 year diagnosis delay. Methods Patients with myasthenia gravis (N = 387) from Europe (France/Germany/Italy/Spain/United Kingdom) and their physicians participated in the ...
Elena Cortés‐Vicente, Andras J. Borsi, Charlotte Gary, Wim G.J. Noel, Jennifer M.S. Lee, Wisam Karmous, Qiaoyi Zhang, Kavita H. Gandhi, Alberto E. Batista, Jonathan J. DeCourcy, Sophie G. Barlow, Shiva L. Birija, Gregor A. Gibson   +12 more
wiley   +1 more source

Diaphragmatic Palsy Due to a Paraneoplastic Autoimmune Syndrome Revealed by Checkpoint Inhibitors

Reports
Background and Clinical Significance: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but may underlie diverse and potentially life-threatening immune-related adverse events (irAEs).
Jean-Baptiste Destival, Jean-Marie Michot, Cécile Cauquil, Nicolas Noël, Salima Hacein-Bey-Abina, Pascale Chrétien, Olivier Lambotte   +6 more
doaj   +1 more source

Pseudomyopathic Changes in Needle Electromyography in Lambert-Eaton Myasthenic Syndrome

Case Reports in Neurological Medicine, 2013
Lambert-Eaton myasthenic syndrome (LEMS) is a rare presynaptic disorder of the neuromuscular junction in association with cancer and subsequently in cases in which no neoplasm has been detected (O’Neill et al., 1988).
Teppei Komatsu, Kota Bokuda, Toshio Shimizu, Tetsuo Komori, Reiji Koide   +4 more
doaj   +1 more source

Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]

, 1982
The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Baranyi, Ben-Ari, Brismar, Brown, Buckle, Collins, Constanti, DiFrancesco, Dingemanse, Galvan, Galvan, Galvan, Gerrit Ten Bruggencate, Gilbey, Golenhofen, Halliwell, Heinemann, Jankowska, Jefferys, Kocsis, Lemeignan, Lipicky, Llinaś, Lundh, Martin Galvan, Matthews, McAfee, Mori, Neuman, Nicholson, Nicoll, Pelhate, Peter Grafe, Pichon, Scholfield, Scholfield, Schwartzkroin, Schwartzkroin, Sherratt, Shimahara, Spyker, Szente, Thesleff, Thompson, Ulbricht, von Haxthausen, Yanagisawa, Yeh   +47 more
core   +1 more source