Results 131 to 140 of about 42,713 (231)

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, Volume 293, Issue 15, Page 4624-4644, August 2026.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Nuclear Lamins: A Molecular Bridge Coupling Extracellular Mechanical Cues to Intranuclear Signal Transduction and Gene Regulation. [PDF]

Int J Mol Sci
Yang S, Liu H, Kou H, Lai L, Zhang X, Xu Y, Sun Y, Chen B.   +7 more
europepmc   +1 more source

EMF2 deficiency disrupts epigenetic and chromatin organization landscapes, blocking root regeneration competence in Arabidopsis

New Phytologist, Volume 251, Issue 4, Page 1792-1810, August 2026.
EMF2 mutation alters transcriptomic profiles in Arabidopsis calli while retaining responsiveness during root induction. Summary Plant de novo organogenesis depends on callus formation, yet the epigenetic mechanisms governing organ regeneration remain poorly understood.
Zhidan Wang, May Avraham, Tali Mandel, Leor Eshed Williams, Chang Liu   +4 more
wiley   +1 more source

Quantifying intracellular mechanosensitive response upon spatially defined mechano-chemical triggering. [PDF]

Elife
Zare-Eelanjegh E, Lewis RTM, Lüchtefeld I, Kutay U, Zambelli T.   +4 more
europepmc   +1 more source

FMRP‐Mediated Proteasome Regulation: A Novel Mechanism in ALS Pathology

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Schematic model of TDP‐43/TNKS‐mediated proteasome regulation in WT, FMRP‐depleted, and TDP‐43A315T‐Tg ALS neurons. In WT neurons, cytoplasmic TDP‐43 partially sequesters TNKS, maintaining balanced PI31 ribosylation and proteasome activity. FMRP depletion promotes nuclear translocation of TDP‐43, enhances TNKS/PI31 interaction, and increases axonal ...
Pritha Majumder, Asmar Ahsan, Pitchapa Bubphachat, Khadiza Akter, Jeffrey K. Huang, Chi‐Chen Sarah Huang   +5 more
wiley   +1 more source

Polarization increases nuclear stiffness in macrophages despite reduction in lamin A/C levels. [PDF]

NPJ Biol Phys Mech
Elpers MA, Odell J, Henretta SJ, Shu T, Ambekar YS, Saadi H, Woodworth GF, Zipfel WR, Scarcelli G, Holt LJ, Lammerding J.   +10 more
europepmc   +1 more source

Kinetic and Spatial Resolution by dSTORM of miniSOG‐Mediated Proximity Labeling in Mammalian Cells

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Controlled blue‐light illumination defines the kinetic regimes and nanoscale labeling radius of miniSOG in mammalian cells. dSTORM imaging reveals an illumination‐tunable proximal labeling range (∼70–180 nm), establishing quantitative spatial parameters for miniSOG‐mediated photocatalytic tagging and enabling proximity‐labeling strategies.
Benoît Arnould, Alexandria L. Quillin, Aastha, Tatiana F. Flores, Jennifer M. Heemstra   +4 more
wiley   +1 more source

Genetically reprogrammed BMSCs with Lamin B1 depletion enhance bone regeneration for osteoporosis therapy. [PDF]

Front Bioeng Biotechnol
Fu X, Huo S, Cao C, Hsu H, Huang J, Lei Y, Li J, Liu P, Zeng J, Lin S, Liang C.   +10 more
europepmc   +1 more source

Tau oligomerization induces nuclear lamina invagination and chromatin remodeling in Alzheimer's disease. [PDF]

Acta Neuropathol
Yuan S, Essepian N, Roberts R, Sherman E, Wang Q, Erisir A, Jiang L.   +6 more
europepmc   +1 more source

Prelamin A in an <i>Lmna</i> ^L648R/L648R Mouse Model Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss. [PDF]

Arterioscler Thromb Vasc Biol
Wang Y, Joseph LC, Östlund C, Kuriakose G, Hsu W, Michaelis S, Worman HJ.   +6 more
europepmc   +1 more source