Results 111 to 120 of about 42,713 (231)

Obesity Disrupts CtBP2‐Mediated Maintenance of Transcriptional Equilibrium in Hypothalamic Feeding Circuitry

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
CtBP2, a transcriptional corepressor with metabolite sensing capabilities, maintains feeding homeostasis by preventing excessive food intake in the hypothalamic feeding center. CtBP2 limits food intake by inhibiting KLF4 within AgRP neurons and by promoting the inhibitory influence of POMC neurons on AgRP neurons.
Wanpei Chen, Kenta Kainoh, Kenji Saito, Takaaki Matsuda, Daichi Yamazaki, Yuto Kobari, Ayumi Nakata, Nao Aono‐Soma, Takafumi Miyamoto, Yuki Murayama, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Motohiro Sekiya   +15 more
wiley   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

The Lamin Proteins in Nuclear Structure, Functions, and Laminopathies. [PDF]

Cells
Zhao G, Chen Z, Yang C, Liu M, Wang W, Zhang C.   +5 more
europepmc   +1 more source

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

Unveiling New Insights: Reinterpreting DES Mutation, p.Arg383His, Through a Study of an Iranian Family With Isolated Hypertrophic Cardiomyopathy, Implication for Phenotype–Genotype Correlation Analysis

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Desmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies, causing diverse cardiac and skeletal myopathies.
Saeideh Kavousi, Farzad Kamali, Bahareh Rabbani, Mehrdad Behmanesh, Nejat Mahdieh, Mehrdad Noruzinia   +5 more
wiley   +1 more source

Clinical Importance of Autoantibodies to SOX10 and Lamin A/C as Potential Biomarkers in Sera From Vitiligo Patients. [PDF]

Ann Dermatol
Kim JH, Ju HJ, Yoo DW, Bae JM, Lee S, Lee SC, Kim KH.   +6 more
europepmc   +1 more source

Exosomal TGM2 From Hypoxia‐Primed Olfactory Mucosa MSCs Attenuates Senescent Astrocytes via NRF1/TFAM Signaling in Parkinson's Disease

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Hypoxia‐preconditioned olfactory mucosa mesenchymal stem cells (OM‐MSCs) release exosomes enriched with transglutaminase 2 (TGM2), which are taken up by astrocytes. Inside the nucleus, TGM2 activates NRF1, leading to the upregulation of TFAM. This enhances mitochondrial function by reducing mitochondrial DNA (mtDNA) leakage and improving mitochondrial ...
Xiqi Hu, Yuchang Liang, Hong Fan, Wenqi Fan, Zijie Wang, Ya‐nan Ma, Peipei Song, Ying Xia   +7 more
wiley   +1 more source

Optimized detection of caspase-6 activation in a murine inflammation model to inform neurodegenerative disease therapies. [PDF]

PLoS One
Sagarbarria I, Seo J, Smith AJ, Vazey EM, Tremblay KD, Mager J, Hardy JA.   +6 more
europepmc   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source