Results 31 to 40 of about 227,164 (251)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Axis Screw Fixation – A Step-by-Step Review of the Surgical Techniques
Brazilian Neurosurgery, 2017 In this article, we present the techniques of axis screw fixation (laminar, pars, pedicle and transarticular screws), discussing the indications and contraindications of each one, as well as surgical tips and anatomical landmarks.
Andrei F. Joaquim, K. Daniel Riew
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Lamina-associated polypeptide 2 (LAP2) expression patterns in transformed and cancer cells [PDF]
, 2009 The Lamina-associated polypeptide two (LAP2) proteins comprising three human isoforms, LAP2 +- LAP2β and LAP2 have been shown to provide a structural framework in the nucleus and to facilitate nuclear assembly and disassembly during the cell ...
Ward, Michelle Claire
core +1 more source
Crosstalk between mitotic reassembly and repair of the nuclear envelope
NucleusIn eukaryotic cells, the nuclear envelope (NE) is a membrane partition between the nucleus and the cytoplasm to compartmentalize nuclear contents. It plays an important role in facilitating nuclear functions including transcription, DNA replication and ...
Yohei Kono, Takeshi Shimi
doaj +1 more source
The Long-Time Chronoamperometric Current at an Inlaid Microband (or Laminar) Electrode
Sensors, 2013 In this article, we derive an approximate asymptotic analytical expression for the long-time chronoamperometric current response at an inlaid microband (or laminar) electrode.
Christopher G. Bell
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Indian Journal of OphthalmologyIntroduction: The osteo-odonto-keratoprosthesis (OOKP) is the most durable device among all keratoprostheses (KPros) to date. The aim of this study was to present a brief overview of the long-term outcomes and key lessons learned from this cohort ...
Christopher Liu +3 more
doaj +1 more source
The agrin gene codes for a family of basal lamina proteins that differ in function and distribution [PDF]
, 1992 We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction.
Tsim, K. W. +13 more
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source