Cell Adhesion & Migration, 2013 Laminins are large molecular weight glycoproteins constituted by the assembly of three disulfide-linked polypeptides, the α, β and γ chains. The human genome encodes 11 genetically distinct laminin chains.
M. Aumailley
semanticscholar +5 more sources
Laminin concentration in ascites of patients with hepatic cirrhosis and peritoneal carcinomatosis [PDF]
Brazilian Journal of Medical and Biological Research, 2005 Laminin levels in ascitic fluid have been proposed as a marker for neoplastic ascites. We compared the concentration of laminin in serum and in ascitic fluid from patients with hepatic cirrhosis and peritoneal carcinomatosis and assessed the diagnostic ...
R.M. Catarino +3 more
doaj +4 more sources
Isolation and characterization of a laminin-binding protein from rat and chick muscle. [PDF]
, 1988 A major laminin-binding protein (LBP), distinct from previously described LBPs, has been isolated from chick and rat skeletal muscle (Mr 56,000 and 66,000, respectively).
Frazer, KA +3 more
core +2 more sources
Laminin-derived peptide drives the cardiomyogenic potential and cardiac cells functionality [PDF]
Frontiers in Bioengineering and BiotechnologyLaminin represents a major component of the basement membrane in cardiac tissue. Through integrins binding, laminin can sustain cell adhesion, proliferation, differentiation and mechanotransduction.
Simona Casarella +7 more
doaj +2 more sources
Structural mechanism of laminin recognition by integrin
Nature Communications, 2021 Recognition of laminin by integrin receptors is central to the epithelial cell adhesion to basement membrane, but the structural background of this molecular interaction remained elusive.
T. Arimori +7 more
semanticscholar +1 more source
Comparison of Two Diagnostic Assays for Anti-Laminin 332 Mucous Membrane Pemphigoid
Frontiers in Immunology, 2021 Anti-laminin 332 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by predominant mucosal lesions and autoantibodies against laminin 332.
Stephanie Goletz +10 more
doaj +1 more source
Keratinocyte-targeted expression of human laminin γ2 rescues skin blistering and early lethality of laminin γ2 deficient mice. [PDF]
PLoS ONE, 2012 Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin chains. Laminin-332 modulates epithelial cell processes, such as adhesion, migration, and differentiation and is prominent in many embryonic and adult ...
Tracy L Adair-Kirk +9 more
doaj +1 more source
Frontiers in Immunology, 2021 Laminin-332 pemphigoid is a rare and severe autoimmune blistering disease, caused by IgG autoantibodies targeting laminin-332 in the dermal-epidermal basement zone.
Lei Bao +13 more
doaj +1 more source
Laminin and Integrin in LAMA2-Related Congenital Muscular Dystrophy: From Disease to Therapeutics
Frontiers in Molecular Neuroscience, 2020 Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating neuromuscular disease caused by mutations in the LAMA2 gene. These mutations result in the complete absence or truncated expression of the laminin-α2 chain.
Pamela Barraza-Flores +3 more
doaj +1 more source
Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle [PDF]
, 2010 Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan.
Brockington, M +7 more
core +11 more sources