Results 21 to 30 of about 217,252 (285)
Distinct roles for laminin globular domains in laminin alpha1 chain mediated rescue of murine laminin alpha2 chain deficiency. [PDF]
PLoS ONE, 2010 BACKGROUND: Laminin alpha2 chain mutations cause congenital muscular dystrophy with dysmyelination neuropathy (MDC1A). Previously, we demonstrated that laminin alpha1 chain ameliorates the disease in mice.
Kinga I Gawlik +4 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Extracellular matrix, especially laminin‐221, may play crucial roles in viability and survival of human‐induced pluripotent stem cell‐derived cardiomyocytes (hiPS‐CMs) after in vivo transplant.
Takaaki Samura +12 more
doaj +1 more source
Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes. [PDF]
PLoS ONE, 2014 We describe the detailed structural investigation of nidogen-1/laminin γ1 complexes using full-length nidogen-1 and a number of laminin γ1 variants. The interactions of nidogen-1 with laminin variants γ1 LEb2-4, γ1 LEb2-4 N836D, γ1 short arm, and γ1 ...
Philip Lössl +9 more
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Frontiers in Oncology, 2022 Laminin is an extracellular matrix multidomain trimeric glycoprotein, that has a potential role in tumor progression. Here, we studied the effects of non-small cell lung cancer (NSCLC) cells interaction on laminin and explored the underlying mechanism of
Xiaopeng Zhao +6 more
doaj +1 more source
Autoimmunity against laminin 332
Frontiers in Immunology, 2023 Laminin 332 is a heterotrimeric structural protein of the basal membrane zone (BMZ) of the skin and adjacent mucosal tissues. The importance of laminin 332 for the structural integrity of the BMZ is demonstrated by mutations in any of the three genes ...
Sabrina Patzelt +2 more
doaj +1 more source
Improvement of human embryonic stem cell-derived retinal pigment epithelium cell adhesion, maturation, and function through coating with truncated recombinant human vitronectin [PDF]
International Journal of Ophthalmology, 2021 AIM: To explore an xeno-free and defined coating substrate suitable for the culture of H9 human embryonic stem cell-derived retinal pigment epithelial (hES-RPE) cells in vitro, and compare the behaviors and functions of hES-RPE cells on two culture ...
Xin-Yue Zhu +7 more
doaj +1 more source
Stable, covalent attachment of laminin to microposts improves the contractility of mouse neonatal cardiomyocytes. [PDF]
, 2014 The mechanical output of contracting cardiomyocytes, the muscle cells of the heart, relates to healthy and disease states of the heart. Culturing cardiomyocytes on arrays of elastomeric microposts can enable inexpensive and high-throughput studies of ...
Ashley, Euan A +3 more
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Fluids and Barriers of the CNS, 2022 Background Unlike other proteins that exhibit a diffusion pattern after intracerebral injection, laminin displays a vascular pattern. It remains unclear if this unique vascular pattern is caused by laminin-receptor interaction or laminin self-assembly ...
Jingsong Ruan +3 more
doaj +1 more source
Effect of laminin 332 on motility and invasion in bladder cancer
Kaohsiung Journal of Medical Sciences, 2013 We examined the correlation between laminin 332 and malignancy in bladder cancer patients, and, using a strain of invasive bladder cancer cells, determined whether laminin 332 causes bladder cancer motility and invasion.
Sung-Gu Kang +11 more
doaj +1 more source
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
Nature Communications, 2018 Laminin, as a key component of the basement membrane extracellular matrix (ECM), regulates tissue morphogenesis. Here, we show that multiple laminin isoforms promiscuously bind to growth factors (GFs) with high affinity, through their heparin-binding ...
J. Ishihara +6 more
semanticscholar +1 more source