Results 41 to 50 of about 125,741 (149)

Uncoupled responses of Smad4-deficient cancer cells to TNFα result in secretion of monomeric laminin-γ2

Molecular Cancer, 2010
Background Functional loss of the tumor suppressor Smad4 is involved in pancreatic and colorectal carcinogenesis and has been associated with the acquisition of invasiveness.
Schmiegel Wolff, Meyer Helmut E, Böckmann Miriam, Becker Heiko, Malas M Bassel, Klein-Scory Susanne, Warscheid Bettina, Zboralski Dirk, Simon-Assmann Patricia, Schwarte-Waldhoff Irmgard   +9 more
doaj   +1 more source

Lung development in laminin γ2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation

Respiratory Research, 2006
Background Laminin γ2 (Lamc2), one of the polypeptides in laminin-332 (laminin-5), is prominent in the basement membrane of alveolar walls and airways of developing and adult lung.
Uitto Jouni, Meneguzzi Guerrino, Schlueter Jessica A, Pulkkinen Leena, Nguyen Nguyet M, Senior Robert M   +5 more
doaj   +1 more source

Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche [PDF]

, 2016
\ua9 2015 European Association for the Study of the Liver.Background & Aims Cancer stem cells (CSCs) are thought to be persistent in tumours due to their chemoresistance and to cause relapse and metastasis.
Petz M, Gremeaux L, Vankelecom H, Van Den Broeck A, Wouters J, Giannelli G, Topal B, Dolle L, Mikulits W, Govaere O, Komuta M, Verhulst S, Van Den Eynde K, Van Vlierberghe H, Ceulemans A, Van Grunsven LA, Roskams T, Nevens F, Vandewynckel Y-P   +18 more
core   +4 more sources

Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofluorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literature

Dermatologica Sinica, 2011
Antiepiligrin cicatricial pemphigoid (AECP) is a chronic autoimmune subepidermal blistering disease characterized by clinical features of cicatricial pemphigoid and circulating IgG antibasement membrane autoantibodies directed against laminin 332.
Chih-Pin Chen, Richard Plunkett, Raminder Grover, Song-Jen Hong   +3 more
doaj   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons [PDF]

, 2011
Laminin-332 is a major component of the dermo-epidermal skin basement membrane and maintains skin integrity. The transduction of mechanical force into electrical signals by sensory endings in the skin requires mechanosensitive channels.
Jing Hu, Sierra, Yinth Andrea Bernal, Poole, Kate, Lewin, G.R., Oliveira, Beatriz E., Bruckner-Tuderman, Leena, Beatriz E Oliveira, Duarte, N., Bernal-Sierra, Yinth-Andrea, Manuel Koch, Koch, M., Gary R Lewin, Bernal Sierra, Y.A., Leena Bruckner-Tuderman, Lewin, Gary R., Neuza Duarte, Duarte, Neuza, Oliveira, B.E., Hu, J., Oliviera, Beatriz E, Li-Yang Chiang, Poole, K., Koch, Manuel, Hu, Jing, Yinth Andrea Bernal Sierra, Chiang, L.Y., Kate Poole, Bruckner-Tuderman, L., Oliveira, Beatriz E, Chiang, Li Yang, Chiang, Li-Yang   +30 more
core   +1 more source

Modified Titanium Dental Implants: The Current Progress of Soft‐Tissue Integration Methods

Advanced NanoBiomed Research, EarlyView.
Dental implants are an established solution for tooth loss, yet achieving soft tissue integration (STI) around the transmucosal region remains a challenge. The natural tooth–gingiva interface is poorly replicated on titanium implants. This review explores surface modification strategies, ranging from surface chemistry and topography to biological ...
Daniel De Maria, Amy Gelmi, Peter C. Sherrell, Stefan Di Medio, Nhiem Tran, Kate Fox   +5 more
wiley   +1 more source

Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins. [PDF]

PLoS ONE, 2016
Refined methods for maintaining specific functions of isolated hepatocytes under xeno-free and chemical defined conditions is of great importance for the development of hepatocyte research and regenerative therapy.
Masaaki Watanabe, Helen Zemack, Helene Johansson, Louise Hagbard, Carl Jorns, Meng Li, Ewa Ellis   +6 more
doaj   +1 more source

A Systematic Review of Topical and Systemic Gentamicin for Wound Healing in Patients With Junctional and Dystrophic Epidermolysis Bullosa

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Epidermolysis bullosa (EB) is an inherited mechanobullous genodermatosis caused by a mutation in genes encoding proteins integral to skin integrity. Premature termination codon readthrough therapies, such as gentamicin, have promise in facilitating full‐length protein expression in patients with EB.
Kelvin Truong, Joseph Joseph, Deborah Poh, Orli Wargon, Artiene Tatian   +4 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source