Myonuclear alterations associated with exercise are independent of age in humans
The Journal of Physiology, Volume 603, Issue 13, Page 3755-3775, 1 July 2025.Abstract figure legend Structural and mechanical properties of myonuclei in trained young and aged individuals. In skeletal muscle fibres from trained individuals, myonuclei are more spherical, have greater lamin A and are stiffer compared to untrained counterparts.
E. Battey +15 more
wiley +1 more source
Cellular Senescence - its role in cancer and the response to ionizing radiation [PDF]
, 2011 © 2011 Sabin and Anderson; licensee BioMed Central Ltd. This article is available through the Brunel Open Access Publishing Fund. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http ...
Rebecca J Sabin, Rhona M Anderson
core +2 more sources
The wide and growing range of lamin B-related diseases: from laminopathies to cancer [PDF]
, 2022 Camilla Evangelisti +7 more
openalex +1 more source
Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells [PDF]
, 2011 Background Tumor-associated macrophages (TAMs) are alternatively activated cells induced by interleukin-4 (IL-4)-releasing CD4+ T cells. TAMs promote breast cancer invasion and metastasis; however, the mechanisms underlying these interactions between ...
Mei Yang +8 more
core +3 more sources
Resveratrol: a Sirtuin Activator and the Fountain of Youth [PDF]
, 2015 BACKGROUND: An organism\u27s lifespan is inevitably accompanied by the aging process, which involves functional decline, a steady increase of a plethora of chronic diseases, and ultimately death.
Dewi, N. M. (Nurrani) +2 more
core +4 more sources
The laminopathies: nuclear structure meets disease
Current Opinion in Genetics & Development, 2003 Most inherited diseases are associated with mutations in a specific gene. Sometimes, mutations in two or more different genes result in diseases with a similar phenotype. Rarely do different mutations in the same gene result in a multitude of seemingly different and unrelated diseases.
Cancer and Developmental Biology Laboratory, National Cancer Institute at Frederick, PO Box B, Frederick, Maryland 21702, USA ( host institution ) +4 more
openaire +3 more sources
Clinical and diagnostic difficulties in management of patients with laminopathies
Российский кардиологический журнал, 2019 Mutations in the LMNA gene cause developing of several phenotypes, both with isolated involvement of cardiac, muscle, adipose and bone tissues, and with their combination.
O. V. Melnik +11 more
doaj +1 more source
Nestor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation [PDF]
, 2014 Background - Premature aging syndromes recapitulate many aspects of natural aging and provide an insight into this phenomenon at a molecular and cellular level.
Ashton, Nicholas W. +9 more
core +3 more sources
Genomic analysis of a novel pathogenic variant in the gene LMNA associated with cardiac laminopathies found in Ecuadorian siblings: A case report [PDF]
, 2023 Patricia Guevara‐Ramírez +9 more
openalex +1 more source
Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective SteatohepatitisSummary
Cellular and Molecular Gastroenterology and Hepatology, 2017 Background & Aims: Lamins are nuclear intermediate filament proteins that comprise the major components of the nuclear lamina. Mutations in LMNA, which encodes lamins A/C, cause laminopathies, including lipodystrophy, cardiomyopathy, and premature aging
Raymond Kwan +11 more
doaj +1 more source