Regulating the levels of key factors in cell cycle and DNA repair: New pathways revealed by lamins [PDF]
, 2011 Spatial and temporal organization of the genome represents an additional step in the regulation of nuclear functions. The nuclear lamina, a polymeric meshwork formed by lamins (A/C and B type) and lamin-associated proteins, plays a key role in the ...
Gonzalez-Suarez, Ignacio +2 more
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BMC Cardiovascular Disorders, 2019 Background Patients with some mutations in the lamin A/C (LMNA) gene are characterized by the presence of dilated cardiomyopathy (DCM), conduction abnormalities, ventricular tachyarrhythmias (VT), and sudden cardiac death (SCD). Various clinical features
Tetsuro Yokokawa +12 more
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Inflammatory myopathy in the context of an unusual overlapping laminopathy
Archives of Endocrinology and Metabolism, 2018 Summary Laminopathies are genetic disorders associated with alterations in nuclear envelope proteins, known as lamins. The LMNA gene encodes lamins A and C, and LMNA mutations have been linked to diseases involving fat (type 2 familial partial ...
Cristina Guillín-Amarelle +8 more
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Investigating pediatric disorders with induced pluripotent stem cells [PDF]
, 2018 The study of disease pathophysiology has long relied on model systems, including animal models and cultured cells. In 2006, Shinya Yamanaka achieved a breakthrough by reprogramming somatic cells into induced pluripotent stem cells (iPSCs).
Cadar, Adrian G. +3 more
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Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency.
PLoS Biology, 2020 The nuclear lamina protein lamin A/C is a key component of the nuclear envelope. Mutations in the lamin A/C gene (LMNA) are identified in patients with various types of laminopathy-containing diseases, which have features of accelerated aging and ...
Lei Xiong +8 more
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Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells. [PDF]
, 2017 published_or_final_versio
Cai, Z +7 more
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Letter by Barriales-Villa et al Regarding Article, “Development and Validation of a New Risk Prediction Score for Life-Threatening Ventricular Tachyarrhythmias in Laminopathies” [PDF]
, 2019 Roberto Barriales‐Villa +2 more
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Laminopathies: Involvement of structural nuclear proteins in the pathogenesis of an increasing number of human diseases [PDF]
, 2004 Nadir M. Maraldi +6 more
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Novel insights into the disease etiology of laminopathies [PDF]
, 2013 Chin Yee Ho +2 more
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SPANX Regulation of LAMIN A/C Network: Perspectives in Cancer and Laminopathies
, 2020 Ikrame Lazar, Bertrand Fabre
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