Results 171 to 180 of about 15,070 (269)

Developmental regulation of linkers of the nucleoskeleton to the cytoskeleton during mouse postnatal retinogenesis [PDF]

, 2013
Hodzic, Didier, Kolb, Thorsten, Razafsky, David S, Ward, Candace L   +3 more
core   +2 more sources

Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics. [PDF]

PNAS Nexus
Yang BA, Vesga-Castro C, Monteiro da Rocha A, Newton I, Shcherbina A, Wong SW, Fraczek PM, Larouche JA, Hiraki H, Baker BM, Shin JW, Takayama S, Thouless MD, Aguilar CA.   +13 more
europepmc   +1 more source

Pharmacological Inhibition of EZH2 by GSK‐343 Attenuates Neuroinflammation in a Mouse Model of Spinal Cord Injury

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
In a mouse model of spinal cord injury, pharmacological inhibition of EZH2 with GSK‐343 reduces tissue damage and neuronal demyelination. GSK‐343 suppresses the EZH2/TRAF6/NF‐κB signaling pathway, leading to attenuation of neuroinflammation and innate immune activation. These effects promote early neuroprotection and improved locomotor recovery in vivo.
Yinhui Kang, Deborah Mannino, Valentina Bova, Alberto Repici, Bulzomì Maria, Ahmed Hasan, Antonio Catalfamo, Jia Yang, Marika Lanza, Alessia Filippone   +9 more
wiley   +1 more source

Probing Nanomechanics by Direct Indentation Using Nanoendoscopy-AFM Reveals the Nuclear Elasticity Transition in Cancer Cells. [PDF]

ACS Appl Nano Mater
Ichikawa T, Kono Y, Kudo M, Shimi T, Miyashita N, Maesaka T, Ishibashi K, Sivashanmugan K, Yoshida T, Miyazawa K, Hanayama R, Hirata E, Miyata K, Kimura H, Fukuma T.   +14 more
europepmc   +1 more source

PBX1 Improves Cognition and Reduces Amyloid‐β Pathology in APP/PS1 Mice by Transcriptionally Activating the CRTC2–CREB Pathway

Aging Cell, Volume 25, Issue 1, January 2026.
We found that the transcription factor PBX1 is markedly downregulated in patients with Alzheimer's disease and in disease models. Restoring PBX1 reduces Aβ pathology and rescues cognitive deficits. Mechanistically, PBX1 directly activates the transcription of CRTC2 and enhances p‐CREB signaling, thereby conferring neuroprotection.
Zinan Liu, Xiangyuan Meng, Rifeng Lu, Xiaoting Meng, Siyao Li, Yujie Wang, Xinpeng Liu, Xiaomei Liu, Jinyu Liu   +8 more
wiley   +1 more source

The molecular basis of lamin-specific chromatin interactions. [PDF]

Nat Struct Mol Biol
Wang B, Kronenberg-Tenga R, Rosti V, Di Patrizio Soldateschi E, Luo Q, Iannacchero UM, Pinet L, Eibauer M, Boujemaa-Paterski R, Schuler B, Lanzuolo C, Medalia O.   +11 more
europepmc   +1 more source

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age‐Related Diabetes in Mice

Aging Cell, Volume 25, Issue 1, January 2026.
hAMSC‐sEVs rejuvenate β cells and improve glycaemic control via the miR‐21‐5p/IL‐6RA/STAT3/MCU axis, restoring mitochondrial Ca2+ homeostasis and insulin secretion in aged T2DM mice. ABSTRACT Targeting senescent pancreatic β‐cells represents a promising therapeutic avenue for age‐related diabetes; however, current anti‐senescence strategies often ...
Lei Xiao, Zicheng Zhang, Tong Li, Yuyin Jiang, Yuanxin Liu, Tingting Lv, Lianju Qin, Yunxia Zhu, Wei Tang   +8 more
wiley   +1 more source

Mechanical signal-chromatin interactions: molecular networks from nuclear membrane force transmission to epigenetic regulation. [PDF]

Front Med (Lausanne)
Yang S, Liu H, Chen B, Kou H, Lai L, Zhang X, Xu Y, Sun Y.   +7 more
europepmc   +1 more source

Multi‐Omics Analysis Reveals Photodynamic Therapy Ameliorating Skin Photoaging by Improving Cellular Senescence Through Mitohormesis‐Mediated Reduction of Citrate Content

Aging Cell, Volume 25, Issue 1, January 2026.
Ultraviolet‐induced skin photoaging involves cellular senescence. Low‐dose photodynamic therapy (PDT) counteracts this by triggering mitochondrial ROS and mitohormesis, which improve metabolism and ameliorate senescence, leading to reduced wrinkles and enhanced skin barrier.
Yu Yan, Qihang Chang, Yun Wu, Yiting Zhao, Guorong Yan, Zhi Cao, Haiyan Zhang, Xiuli Wang, Qingyu Zeng, Peiru Wang   +9 more
wiley   +1 more source

Phosphorylation-dependent modulation of the Lamin A/C-EZH2 complex regulates epithelial-mesenchymal plasticity. [PDF]

Nucleic Acids Res
Ak B, Saha S, Sengupta K.
europepmc   +1 more source