Results 171 to 180 of about 18,044 (328)
Binding of matrix attachment regions to nuclear lamin is mediated by the rod domain and depends on the lamin polymerization state [PDF]
, 1996 Kun Zhao +4 more
openalex +1 more source
Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis
Aging Cell, EarlyView.In aging or fibrotic fibroblasts, NUDT21 is downregulated, leading to alternative polyadenylation/3′ UTR shortening of STAT3 pathway genes, enhancing their protein expression and promoting STAT3 phosphorylation. Activated STAT3 signaling subsequently drives the expression and release of senescence‐associated secretory phenotype (SASP) factors, thereby ...
Jingjing Huang +14 more
wiley +1 more source
Aging Cell, EarlyView.cTAGE5 regulates LBR trafficking between the ER and the nucleus membrane to maintain the integrity of both the ER and the nuclear envelope. cTAGE5 KO results in LBR retention in the ER, reduced stability, and subsequent disruption of nuclear envelope integrity. ABSTRACT cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER‐to‐Golgi trafficking,
Yaqing Wang +9 more
wiley +1 more source
Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment
Aging Cell, EarlyView.Local growth hormone (GH) is expressed and secreted by senescent cells in the aging human colon. GH triggers epithelial‐to‐mesenchymal transition and activates colon cell motility by regulating extracellular matrix proteins, inducing cytoskeleton rearrangement and altering cell motility protein phosphorylation.
Vera Chesnokova +8 more
wiley +1 more source
Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease
Aging Cell, EarlyView.Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease‐Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single‐nucleus RNA‐seq from human brain tissues identified cholesterol‐related senescence gene co‐expression modules linked to microglial senescence.
Boyang Li +8 more
wiley +1 more source
Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.
, 1994 Valerie L. Goss +5 more
openalex +1 more source
Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B) [PDF]
, 2000 Antoine Muchir
openalex +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose The increasing number of cancer survivors has caused growing concern over chemotherapy‐induced cardiotoxicity. This study aimed to investigate a novel human model of cardiotoxicity and explore cardioprotection. Experimental Approach Living myocardial slices (LMS) were obtained from explanted end‐stage heart failure ...
Jort S. A. van der Geest +15 more
wiley +1 more source