Results 181 to 190 of about 15,070 (269)

Comparing Functional Consequences of Human iPSC‐Microglia and Neural Stem Cell‐Derived Extracellular Vesicles in Mitigating Cognitive Decline in Alzheimer's Disease

Aging Cell, Volume 25, Issue 1, January 2026.
Systemic (retro‐orbital vein) recurrent injections of human iPSC‐microglia and neural stem cell‐derived extracellular vesicles in a 5xFAD mouse model of Alzheimer's disease significantly improve cortex‐dependent cognitive function, reduce amyloid beta plaques, mitigate microglial and astrocytic activation, deliver neuroprotective miRNA cargo, and ...
Robert P. Krattli Jr., Mineh Markarian, Shreya Madan, Devyani Swami, Amanda McQuade, Janet E. Baulch, Matthew Blurton‐Jones, Munjal M. Acharya   +7 more
wiley   +1 more source

A Reporter Platform to Study Therapy-Induced Senescence in Live Cancer Cells. [PDF]

Small Methods
van de Grint J, Huang M, Sangers R, Odijk H, Reuvers T, Heredia-Genestar JM, Raams A, Kan TW, Pothof J, Kanaar R, Kuijten MMP.   +10 more
europepmc   +1 more source

Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy‐Induced Senescent Cells

Aging Cell, Volume 25, Issue 1, January 2026.
In the course of TIS, cells undergo a profound epigenomic reorganization that underlies the development of a senescence‐associated phenotype and formation of an inflammatory microenvironment. ABSTRACT Cellular senescence is a fundamental biological process contributing to aging, often accompanied by extensive chromatin remodeling.
Ge Zhang, Wei Zhang, Changxu Wang, Zhirui Jiang, Qixia Xu, Haipeng Li, James L. Kirkland, Gang Wei, Yu Sun   +8 more
wiley   +1 more source

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate. [PDF]

Nat Cell Biol
Marin HC, Allen C, Simental E, Martin EW, Panning B, Al-Sady B, Buchwalter A.   +6 more
europepmc   +1 more source

CpG Methylation‐Driven Pleiotropic Spliced Isoforms of PRSS3 Facilitate Gastric Intratumor Heterogeneity and Metastasis

Cancer Science, Volume 117, Issue 1, Page 33-49, January 2026.
Aberrant spliced isoforms of PRRS3, which are regulated by epigenetic mechanisms, contribute to increased cellular heterogeneity and promote metastasis in gastric cancer (GC). This study underscores the significant involvement of methylation‐driven alternative splicing in tumor heterogeneity and suggests that these spliced isoforms may serve as more ...
Mengdi Pang, Hanli Xu, Duoduo Li, Meiying Zhang, Daichuan Chen, Rongmeng Tian, Jie Gu, Nafisa Alimu, EnKai Wang, Ziyun Zhou, Xinyi Li, Qihang Peng, Yuqi He, Shuye Lin, Mingzhou Guo, Jiaqiang Huang   +15 more
wiley   +1 more source

Quantifying conformational heterogeneity of 3D genome organization in fruit fly. [PDF]

PLoS One
Mali S, Tolokh IS, Cross E, Onufriev AV.
europepmc   +1 more source

YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice

Cell Proliferation, Volume 59, Issue 1, January 2026.
Specifically ablating Ykt6 in pre‐meiotic germ cells and meiotic spermatocytes leads to complete sterility and meiotic arrest in conditional knockout male mice. YTK6 is required for stabilising intercellular bridges between spermatocytes due to its key role in maintaining protein homeostasis and vesicular transport‐dependent functions in spermatocytes,
Jie Cen, Xiaochen Yu, Ziqi Wang, Wenbo Liu, Jianze Xu, Qian Fang, Fei Gao, Yongzhi Cao, Hongbin Liu   +8 more
wiley   +1 more source

The accumulation of progerin underlies the loss of aortic smooth muscle cells in Hutchinson-Gilford progeria syndrome. [PDF]

Cell Death Dis
Kim PH, Kim JR, Heizer PJ, Jung H, Tu Y, Presnell A, Scheithauer J, Yu RG, Young SG, Fong LG.   +9 more
europepmc   +1 more source

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

The FEBS Journal, Volume 293, Issue 2, Page 396-417, January 2026.
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury, Xiaoli Wang, Richard I. Han, Manga Motrapu, Ashley G. Boice, Yuya Nakatani, Sofia Vargas‐Hernandez, Julia F. Love, Claude Chew, Sandra L. Grimm, Dereck Mezquita, Frank M. Mason, Elisabeth D. Martinez, Cristian Coarfa, Cheryl L. Walker, Anna‐Karin Gustavsson, Ruhee Dere   +16 more
wiley   +1 more source

Lamin A/C protects chromatin accessibility during mechanical loading in human skeletal muscle. [PDF]

Cell Commun Signal
Jabre S, Cherchame E, Pinzón N, Lemerle E, Bitoun M, Coirault C.   +5 more
europepmc   +1 more source