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Reactions Weekly, 2018 Lamotrigine is a second-generation antiepileptic drug characterized by a wide range of antiepileptic indications, with an acceptable interaction profile in polytherapy.
Andrea E. Cavanna
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Expert Review of Neurotherapeutics, 2001
Lamotrigine is a newly available antiepileptic drug with a broad spectrum of efficacy and a tolerability profile that is favorable for use in many patients. Problems with rash are related to rate of dose ascension and drug interactions with valproate.
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Lamotrigine is a newly available antiepileptic drug with a broad spectrum of efficacy and a tolerability profile that is favorable for use in many patients. Problems with rash are related to rate of dose ascension and drug interactions with valproate.
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Epilepsia, 1999
Summary:Clinical use of the antiepileptic drug (AED) lamotrigine (LTG) has dramatically increased since its introduction in Europe in 1991 and in the United States in 1994. This article surveys the English‐language literature of LTG published before 1998.
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Summary:Clinical use of the antiepileptic drug (AED) lamotrigine (LTG) has dramatically increased since its introduction in Europe in 1991 and in the United States in 1994. This article surveys the English‐language literature of LTG published before 1998.
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Cochrane Database of Systematic Reviews, 2006
Treating the 20-30% of people with schizophrenia whose symptoms are resistant to treatment can be problematic. Adding lamotrigine to ongoing antipsychotic treatment has shown to be of benefit in preliminary studies.To evaluate the effects of adjuvant lamotrigine for people with schizophrenia and schizophrenia-like psychoses.We searched the Cochrane ...
T S, Premkumar, J, Pick
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Treating the 20-30% of people with schizophrenia whose symptoms are resistant to treatment can be problematic. Adding lamotrigine to ongoing antipsychotic treatment has shown to be of benefit in preliminary studies.To evaluate the effects of adjuvant lamotrigine for people with schizophrenia and schizophrenia-like psychoses.We searched the Cochrane ...
T S, Premkumar, J, Pick
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LAMOTRIGINE OVERDOSE IN A CHILD
Neuropediatrics, 2006The purpose of this article is to describe an unusual presentation of lamotrigine toxicity in an epileptic child treated on a lower than previously reported dosage. This is a case description of a 5-year-old epileptic girl on lamotrigine monotherapy, which caused toxicity. The child presented with ataxia, drowsiness, and acute confusion after ingesting
Muhannad, Daana +4 more
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1995
Lamotrigine is a novel antiepileptic that, although its mechanism is not completely understood, appears to affect voltage‐activated sodium channels, resulting in inhibition of the presynaptic release of the excitatory neurotransmitter glutamate. It is well absorbed after oral administration. Its route of elimination is hepatic glucuronidation, which is
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Lamotrigine is a novel antiepileptic that, although its mechanism is not completely understood, appears to affect voltage‐activated sodium channels, resulting in inhibition of the presynaptic release of the excitatory neurotransmitter glutamate. It is well absorbed after oral administration. Its route of elimination is hepatic glucuronidation, which is
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Clinical Neuropharmacology, 1994
Summary:Lamotrigine (LTG) is a novel antiepileptic drug (AED) with a spectrum of activity in animal models of epilepsy similar to that of phenytoin and carbam‐azepine. In some models it appears to have a broader spectrum and better tolerability than these agents, however.
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Summary:Lamotrigine (LTG) is a novel antiepileptic drug (AED) with a spectrum of activity in animal models of epilepsy similar to that of phenytoin and carbam‐azepine. In some models it appears to have a broader spectrum and better tolerability than these agents, however.
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Journal of Child Neurology, 1997
The pharmacokinetics of lamotrigine have been studied in single and multiple dose studies in animals, normal volunteers, and patients with epilepsy. Lamotrigine exhibits first-order linear pharmacokinetics. Lamotrigine is well absorbed with bioavailability approaching 100%. The absorption is unaffected by food and there is no first-pass metabolism. The
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The pharmacokinetics of lamotrigine have been studied in single and multiple dose studies in animals, normal volunteers, and patients with epilepsy. Lamotrigine exhibits first-order linear pharmacokinetics. Lamotrigine is well absorbed with bioavailability approaching 100%. The absorption is unaffected by food and there is no first-pass metabolism. The
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Epilepsia, 1994
Summary: Clinical trials of lamotrigine (LTG) began in 1984. By November 1992 about 5,800 patient‐years' experience of adverse effects had been compiled. In general, LTG has an acceptable safety profile. Mild central nervous system adverse effects such as ataxia, dizziness, and headache occur significantly more frequently with LTG than with placebo ...
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Summary: Clinical trials of lamotrigine (LTG) began in 1984. By November 1992 about 5,800 patient‐years' experience of adverse effects had been compiled. In general, LTG has an acceptable safety profile. Mild central nervous system adverse effects such as ataxia, dizziness, and headache occur significantly more frequently with LTG than with placebo ...
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