Results 131 to 140 of about 3,129 (150)
Characterisation of LAMP1- and LAMP2A-positive organelles in neurons
Abouward R +9 more
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Immunohistochemical Detection of the Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Formalin-Fixed and Paraffin-Embedded Tissues [PDF]
Methods in Molecular Biology, 2023 Autophagy is crucial for maintaining cellular homeostasis and its deregulation is involved in disease development, including cancer. The key players of chaperone-mediated autophagy (CMA), a particular selective subtype of autophagy, are HSPA8 and LAMP2A.
Sabina Berezowska +2 more
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Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A [PDF]
Autophagy, 2018 Chaperone-mediated autophagy (CMA) is a selective degradative process for cytosolic proteins that contributes to the maintenance of proteostasis. The signaling mechanisms that control CMA are not fully understood but might involve response to stress ...
Ana I Rojo +2 more
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LAMP2A as a therapeutic target in Parkinson disease
Autophagy, 2013 Abnormal aggregation of SNCA/-synuclein plays a crucial role in Parkinson disease (PD) pathogenesis. SNCA levels determine its toxicity, and its accumulation, even to a small extent, may be a risk factor for neurodegeneration.
Maria Xilouri +2 more
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LAMP2A regulates the loading of proteins into exosomes [PDF]
Science Advances, 2022 International audienceExosomes are extracellular vesicles of endosomal origin that are released by practically all cell types across metazoans. Exosomes are active vehicles of intercellular communication and can transfer lipids, RNAs, and proteins ...
Joao Vasco Ferreira +2 more
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Cell ReportsData availability for the manuscript entitled “LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced ...
Yuxin Zhang, Ban Feng
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International Journal of Molecular SciencesAutophagy is the primary intracellular degradation system, and it plays an important role in many biological and pathological processes. Studies of autophagy involvement in developmental processes are important for understanding various processes.
Ivo Jelicic +2 more
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LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles
Autophagy, 2023Wen-qiang Chen, Chunlin Wang, Huixia Lu
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LAMP2A-mediated autophagy involved in Huntington’s disease progression
Biochemical and Biophysical Research Communications, 2021KyoungJoo Cho
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