Results 91 to 100 of about 776,001 (296)
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Articulo: Journal of Urban Research, 2013 The death of landscape has been heralded some time ago; and yet, for at least the past twenty years, we have witnessed its significant return in planning practice. Indeed, there is a consensus aiming to turn landscape into a pertinent object of the urban
Christophe Mager, Laurent Matthey
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
The Degree of Landscape Openness as a Manifestation of Cultural Metamorphose
Quaestiones Geographicae, 2014 The issues of aesthetic assessment of landscapes has now become important due to the need of rational and balanced cultural landscape management and the implementation of the provisions of the European Landscape Convention.
Plit Joanna, Myga-Piątek Urszula
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Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source
Exploratory Excavation at Braye-en-Laonnois, Renge River, 1991: Preliminary Report
Papers from the Institute of Archaeology, 1992 This report is concerned with excavation at Braye-en-Laonnois, Departement Aisne, north-east France, in August and September 1991 by a team from the Institute of Archaeology, University College London, and the University of Durham.
doaj +2 more sources
Land Consolidations in Slovakia, Step Forward, Two Steps Back?
Ekológia (Bratislava), 2015 This article describes the process of land consolidations in Slovakia. Fundamental goals of land consolidation are defined in the paper. Land ownership is briefly described with emphasis on historical development.
Muchová Zlatica +5 more
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FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source