Results 91 to 100 of about 3,501,652 (356)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

PiERF1 regulates cold tolerance in Plumbago indica L. through ethylene signalling

Scientific Reports
Ethylene is a signalling factor that plays a key role in the response of plants to abiotic stresses, such as cold stress. Recent studies have shown that the exogenous application of 1-aminocyclopropane-1-carboxylate (ACC), an ethylene promoter, affects ...
Zi-An Zhao, Yi-Rui Li, Ting Lei, Cai-Lei Liu, Qing-Xiao Zeng, Xuan Liu, Li-Juan Yang, Jia-Ni Li, Su-Ping Gao   +8 more
doaj   +1 more source

Modelling and simulating change in reforesting mountain landscapes using a social-ecological framework [PDF]

, 2010
Natural reforestation of European mountain landscapes raises major environmental and societal issues. With local stakeholders in the Pyrenees National Park area (France), we studied agricultural landscape colonisation by ash (Fraxinus excelsior) to ...
A Gibon, A Gibon, A Gibon, A Mottet, A Otte, Annick Gibon, BJ Fu, BL Turner II, C Fontaine, C Lundstrom, C Monteil, Claude Monteil, CS Holling, D Valbuena, David Sheeren, DC Parker, DC Parker, DG Brown, E Moreira, E Tasser, EJJ Rykiel, F Berkes, F Berkes, F Bousquet, F Bousquet, G Augustins, G Balent, Gérard Balent, J Brandt, J Kolasa, J Wu, JB Dent, JC Castella, JG Wu, JP Deffontaines, K Helming, L An, M Antrop, M Burgi, M Duru, M Duru, M Gellrich, M Muraz, MG Turner, MP Julien, N Andrieu, P Wardle, PH Verburg, QB Le, R Matthews, R Soliva, RB Matthews, RH Økland, RW Kates, S Wagner, SM Manson, Sylvie Ladet, T Berger, T Plieninger, T Streifeneder, TFH Allen, TJ Bontkes, TR Robinson, V Grimm, Z Naveh   +64 more
core   +3 more sources

Decoding multicellular interaction networks–a new horizon in tumor microenvironment research

Molecular Oncology, EarlyView.
Cells in the tumor microenvironment influence tumor establishment and progression through an elaborate array of cellular interactions. Integrating transcriptomic, spatial, and intercellular crosstalk data at single‐cell resolution unveil complex, functionally distinct multicellular circuits.
Roi Balaban, Merav Cohen
wiley   +1 more source

Deceptiveness and Neutrality - the ND family of fitness landscapes [PDF]

, 2009
When a considerable number of mutations have no effects on fitness values, the fitness landscape is said neutral. In order to study the interplay between neutrality, which exists in many real-world applications, and performances of metaheuristics, it is useful to design landscapes which make it possible to tune precisely neutral degree distribution ...
arxiv   +1 more source

Bulletin 22A: Papers in viticulture and Bulletin 22B: Papers in winemaking and wine evaluation [PDF]

, 1978
2 volume set, Papers in viticulture Bulletin 22A: Papers in viticulture; Bulletin 22B; Papers in winemaking and wine evaluation.The papers in these bulletins (22 A and B) were presented at the two courses in Grapes and Wine held at Lincoln College in ...
Department of Horticulture, Landscape and Parks
core  

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

The Connectivity of NK Landscapes' Basins: A Network Analysis [PDF]

arXiv, 2008
We propose a network characterization of combinatorial fitness landscapes by adapting the notion of inherent networks proposed for energy surfaces. We use the well-known family of NK landscapes as an example. In our case the inherent network is the graph where the vertices represent the local maxima in the landscape, and the edges account for the ...
arxiv  

Biochar application regulating soil inorganic nitrogen and organic carbon content in cropland in the Central Europe: a seven-year field study

Biochar
Biochar incorporation into soil has shown potential, in enhancing nitrogen fertilizer (N-fertilizer) efficacy and soil organic carbon content (SOC). This study addresses a critical gap in the literature by investigating the effects of biochar addition ...
Narges Hematimatin, Dušan Igaz, Elena Aydın, Ján Horák   +3 more
doaj   +1 more source

Valoración de paisajes culturales y potencial de los recursos turísticos en un territorio. Estudio de casos: El municipio de Lezo = Valuation of Cultural Landscapes and Potential of the Tourism Resources of a Territory. Case Study: The Municipality of Lezo

Espacio, Tiempo y Forma. Serie VI, Geografía, 2018
La Universidad de Lezo es un pequeño municipio guipuzcoano al que acuden pocos turistas. Esto se debe a su cercanía a otros lugares más atractivos por ser más conocidos y a su industrialización gracias a la localización privilegiada de su territorio. Sin
María Teresa Álvarez Zumeta
doaj   +1 more source