Results 61 to 70 of about 876,835 (299)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
When a large reserve is not large enough to protect part of a population: Blue-and-yellow Macaws (Ara ararauna) in central Brazil [PDF]
Biotemas, 2010 This study aimed to examine movements of the Blue-and-yellow Macaw (Ara ararauna) across boundaries between the Parque Nacional das Emas and adjacent agricultural landscapes, in central Brazil.
Dárius Pukenis Tubelis
doaj
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Changing Fire Governance in Gabon′s Plateaux Bateke Savanna Landscape
Conservation & Society, 2015 In many African savannas, anthropogenic fire regimes are changing for reasons that are poorly understood. However, these changes will likely impact landscapes.
Gretchen Marie Walters
doaj +1 more source
Land, 2020 This study is the first analysis of the influence of the design of the logos of the National and Natural Parks of Spain on social attitudes toward these protected areas (PAs).
Andrés Caballero-Calvo +1 more
doaj +1 more source
Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer [PDF]
, 2020 Anthony R. Cillo +15 more
openalex +1 more source
Compendium : Journal of Comparative Studies = Revista de Estudos Comparatistas, 2022 From the Archive is a special section of Compendium dedicated to republishing texts from the Centre for Comparative Studies’ two-decade history of academic publishing in book form, giving them a new visibility and easier international outreach online. The choice of book chapters and articles to include in this section is based on the way they directly ...
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source