Results 61 to 70 of about 776,001 (296)

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Valtellina e Valchiavenna. Ricorrenze e discontinuità per un’architettura in cerca di identità

ArchAlp, 2020
"Architecture in Valtellina and Valchiavenna remained anchored to ancient traditions until the second half of the twentieth century, when new lifestyles and economic models lead to the so-called “building boom”.
Giacomo Menini
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Taxonomic status and spatial genetic pattern of Taxus in northern and central China: insights from integrative taxonomy, ecology and phylogeography

BMC Plant Biology
Background Phenotypic, ecological, and genetic differences are crucial for species delimitation and understanding speciation. However, the defining the distribution boundaries and mechanisms driving lineage differentiation of Taxus species in northern ...
Chuncheng Wang, Minqiu Wang, Shaolong Yang, Xintong Wu, Shanshan Zhu, Yadan Yan, Jing Xu, Yafeng Wen   +7 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

PiERF1 regulates cold tolerance in Plumbago indica L. through ethylene signalling

Scientific Reports
Ethylene is a signalling factor that plays a key role in the response of plants to abiotic stresses, such as cold stress. Recent studies have shown that the exogenous application of 1-aminocyclopropane-1-carboxylate (ACC), an ethylene promoter, affects ...
Zi-An Zhao, Yi-Rui Li, Ting Lei, Cai-Lei Liu, Qing-Xiao Zeng, Xuan Liu, Li-Juan Yang, Jia-Ni Li, Su-Ping Gao   +8 more
doaj   +1 more source

Strategic aspects of developing spatial structure of recreational landscape strengthening Lithuania’s cultural identity in the context of Baltic states

Journal of Architecture and Urbanism, 2006
Analysis of the potential and resources of each region in the country is necessary for improving the living conditions of an individual. The present task of the Lithuanian recreational system is to allow effective use of recreational resources on the ...
Petras Grecevičius, Romas Marčius
doaj   +1 more source

Landscapes of Production-Landscapes for Consumption [PDF]

International Journal of Public and Private Perspectives on Healthcare, Culture, and the Environment, 2017
This paper is the second part of an exploration into the history and meaning of landscapes, based on a case study of the “must-see” scenic spots or Eight Views (bajing ??) of Linfen County in the south of China's Shanxi province. While the first part focused on the value of these iconic landscapes as sources of identity, here I will show how their ...
openaire   +2 more sources