Results 71 to 80 of about 3,075,932 (287)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Populating the Landscape: A Top Down Approach

, 2006
We put forward a framework for cosmology that combines the string landscape with no boundary initial conditions. In this framework, amplitudes for alternative histories for the universe are calculated with final boundary conditions only.
J. Barrow, J. B. Hartle, J. B. Hartle, S. W. Hawking, Thomas Hertog   +4 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Conflicts between indigenous and scientific concepts of landscape management for wildlife conservation: human-chimpanzee politics of coexistence at Bossou, Guinea

Revue de Primatologie, 2014
Environmental conservation policies in Africa have their origin in the forced establishment of nature reserves during the colonial era. Even after African countries became independent, top-down operation of these reserves continued primarily due to ...
Gen Yamakoshi, Vincent Leblan
doaj   +1 more source

Flaubert’s Landscapes

Compendium : Journal of Comparative Studies = Revista de Estudos Comparatistas, 2022
From the Archive is a special section of Compendium dedicated to republishing texts from the Centre for Comparative Studies’ two-decade history of academic publishing in book form, giving them a new visibility and easier international outreach online. The choice of book chapters and articles to include in this section is based on the way they directly ...
openaire   +2 more sources

09:03 a dozen years to make a state go virtual : LIDAR data use for 3D visualisation of the Maltese Islands [PDF]

, 2013
Creating a new modus operandi for 3D data analysis that covers an entire state is a endearing task which required considerable funding and the integration of various thematic domains that lent an operational hand to spatial analysis in the Maltese state.
Digital Landscape Architecture 2013, Formosa, Saviour   +1 more
core  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Vacuum Selection on the String Landscape [PDF]

, 2007
I examine some non-anthropic approaches to the string landscape. These approaches are based on finding the initial conditions of the universe using the wavefunction of the multiverse to select the most probable vacuum out of this landscape.
Tetteh-Lartey, Edward
core   +5 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

СREATION OF LANDSCAPE MAP USING OPEN SOURCE SOFTWARE (ON THE EXAMPLE OF THE NATIONAL PARK «SMOLENSKOYE POOZERYE»)

InterCarto. InterGIS, 2016
In landscape mapping is no single technique, so each school has its own method of creating maps. However, one of the initial operations, recognized all schools allocation is called the primary matrix – matrix or locations which latched, usually on the ...
T. V. Vatlina, S. P. Evdokimov
doaj   +1 more source