Results 91 to 100 of about 1,420,430 (337)
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
A Detailed Analysis of Contemporary ARM and x86 Architectures [PDF]
, 2013 RISC vs. CISC wars raged in the 1980s when chip area and processor design complexity were the primary constraints and desktops and servers exclusively dominated the computing landscape.
Blem, Emily +2 more
core +2 more sources
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Following nature's design principles & solutions [PDF]
, 2012 This project utilizes the naturally occurring phenomenon of plants and microbial bacteria to communicate, called "cross-talk", as a central approach in addressing humandominated landscape simplification. Through emitting Volatile Organic Compounds (VOCs)
Jackson, Brett M.
core
Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
Citizens contributing in landscape in the Netherlands [PDF]
With the continuing loss of landscape elements and open space, landscape management is gaining importance in tandem with the design of acceptable private and voluntary financing arrangements. Here, we analyze the awareness, involvement, socio-demographic
Graaff, R.P.M., de +2 more
core +1 more source
Waiheke Island : perceptions of the environment : a thesis presented in partial fulfilment of the requirements for the degree of Master of Management at Massey University at Albany, New Zealand [PDF]
, 2002 The need for the sustainable management of resources has been recognised since the early 1980s. However, the concept that the physical landscape is also a resource which needs to be managed and quantified is more recent.
Histen, Suzanne Teresa
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini +13 more
wiley +1 more source