Results 51 to 60 of about 942,623 (281)
Adaptation in tunably rugged fitness landscapes: The Rough Mount Fuji Model
, 2014 Much of the current theory of adaptation is based on Gillespie's mutational landscape model (MLM), which assumes that the fitness values of genotypes linked by single mutational steps are independent random variables. On the other hand, a growing body of
Krug, Joachim +2 more
core +1 more source
Identification of drug resistance mutations in HIV from constraints on natural evolution [PDF]
, 2015 Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape.
Barton, John P. +3 more
core +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Cosmogenic nuclide dating of cave sediments in the Eastern Alps and implications for erosion rates
International Journal of Speleology, 2020 Karstic caves are created by water eroding and corroding rocks that can be dissolved. Since both the spring areas of caves (normally at the valley bottom) as well as the recharge is controlled by superficial processes, the morphology of the cave bears ...
Philipp Häuselmann +3 more
doaj +1 more source
Observations on Palaeogeographical Evolution of Akrotiri Salt Lake, Lemesos, Cyprus
Geosciences, 2021 Akrotiri Salt Lake is located 5 km west of the city of Lemesos in the southernmost part of the island of Cyprus. The evolution of the Akrotiri Salt Lake is of great scientific interest, occurring during the Holocene when eustatic and isostatic movements ...
Miltiadis Polidorou +5 more
doaj +1 more source
Effects of random pinning on the potential energy landscape of a supercooled liquid
, 2019 We use energy landscape methods to investigate the response of a supercooled liquid to random pinning. We classify the structural similarity of different energy minima using a measure of overlap.
de Souza, V. K. +3 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Environmental DNABiodiversity monitoring in difficult‐to‐access areas, such as rugged mountain ranges, is currently challenging and thus often absent. Environmental DNA (eDNA) offers new opportunities to monitor remote or strictly protected areas, as rivers integrate the
Flurin Leugger +5 more
doaj +1 more source
Landscape and Climate Changes in Southeastern Amazonia from Quaternary Records of Upland Lakes
Atmosphere, 2023 The upland lakes (ULs) in Carajás, southeastern Amazonia, have been extensively studied with respect to their high-resolution structural geology, geomorphology, stratigraphy, multielement and isotope geochemistry, palynology and limnology.
José Tasso Felix Guimarães +13 more
doaj +1 more source
Agent Programming in Ciao Prolog [PDF]
, 2001 The agent programming landscape has been revealed as a natural framework for developing “intelligence” in AI. This can be seen from the extensive use of the agent concept in presenting (and developing) AI systems, the proliferation of agent theories, and
Bueno Carrillo, Francisco +8 more
core +2 more sources