Results 71 to 80 of about 942,623 (281)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Cellular Models for River Networks

, 2000
A cellular model introduced for the evolution of the fluvial landscape is revisited using extensive numerical and scaling analyses. The basic network shapes and their recurrence especially in the aggregation structure are then addressed.
A. D. Howard, A. Maritan, A. Rinaldo, A. Rinaldo, A. Rinaldo, A. Rinaldo, A.D. Howard, B. B. Mandelbrot, D.G. Tarboton, D.R. Montgomery, D.R. Montgomery, G. Caldarelli, G.R. Willgoose, Guido Caldarelli, I. Rodriguez-Iturbe, I. Rodriguez-Iturbe, I. Rodriguez-Iturbe, I. Rodriguez-Iturbe, J. Feder, J.T. Hack, K. Sinclair, L. Band, M. Marani, P. Bak, P. La Barbera, R. Rigon, R. Rigon, V. Sapozhnikov, W.E. Dietrich   +28 more
core   +1 more source

Is HIV short-sighted? Insights from a multistrain nested model [PDF]

, 2013
An important component of pathogen evolution at the population level is evolution within hosts. Unless evolution within hosts is very slow compared to the duration of infection, the composition of pathogen genotypes within a host is likely to change ...
Fraser, Christophe, Lythgoe, Katrina A., Pellis, Lorenzo   +2 more
core   +3 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

MOLECULAR EVOLUTION OVER THE MUTATIONAL LANDSCAPE [PDF]

Evolution, 1984
A common observation in phylogenetic comparisons of the amino acid sequences of a particular protein is that the rate of evolution of the protein is nearly constant over extended periods of time. This constancy was first noticed by Zuckerkandl and Pauling (1965) and prompted them to call the amino acid substitution process a "molecular evolutionary ...
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Three‐Dimensional Modeling of the Coevolution of Landscape and Soil Organic Carbon

Water Resources Research, 2019
Soil organic carbon (SOC) is going through rapid reorganization due to anthropogenic influences. Understanding how biogeochemical transformation and erosion‐induced SOC redistribution influence SOC profiles and stocks is critical to our food security and
Qina Yan, Phong V. V. Le, Dong K. Woo, Tingyu Hou, Timothy Filley, Praveen Kumar   +5 more
doaj   +1 more source

Tectonics, volcanism, landscape structure and human evolution in the African Rift [PDF]

, 2000
Tectonic movements and volcanism in the African Rift have usually been considered of relevance to human evolution only at very large geographical and chronological scales, principally in relation to longterm topographic and climatic variation at the ...
Bailey, G., King, G., Manighetti, I.
core  

The sensitivity of landscape evolution models to spatial and temporal rainfall resolution [PDF]

, 2016
© Author(s) 2016. Climate is one of the main drivers for landscape evolution models (LEMs), yet its representation is often basic with values averaged over long time periods and frequently lumped to the same value for the whole basin. Clearly, this hides
Coulthard, Tom J., Skinner, Christopher J.   +1 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source