Results 171 to 180 of about 1,387,202 (292)
GEOME : A web-based landscape genomics geocomputation platform
Landscape ecologists and resource conservation managers increasingly need geo-referenced data but are not trained to efficiently use Geographical Information Systems together with appropriate geo-environmental information and spatial analysis approaches.
Joost, Stéphane, Kalbermatten, Michaël
core
Advanced Science, EarlyView.Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang +6 more
wiley +1 more source
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
, 2013 Analysis of the equine genome began just over a decade ago, culminating in the recent complete sequencing of the horse genome. The availability of the equine whole genome sequence represents the successful completion of an important era of equine genome ...
Chowdhary, Bhanu P.
core
Advanced Science, EarlyView.Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv +14 more
wiley +1 more source
Advanced Science, EarlyView.Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu +18 more
wiley +1 more source
Genetics in medicine : official journal of the American College of Medical Genetics
The increasing availability of personal genomic tests has led to discussions about the validity and utility of such tests and the balance of benefits and harms.
core
The LIFE Programme is the European Union’s instrument to finance projects for the conservation of the environment, biodiversity and the fight against climate change. The aim of the LIFE SySTEMiC Project (Close-to-nature foreSt SusTainablE Management practices under Climate Changes) is to use the “modeling tool” based on genetic diversity to identify ...
Cesare Garosi +4 more
openaire +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Advanced Science, EarlyView.A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia +10 more
wiley +1 more source