Results 71 to 80 of about 1,387,202 (292)

Reefscape Genomics: Leveraging Advances in 3D Imaging to Assess Fine-Scale Patterns of Genomic Variation on Coral Reefs

Frontiers in Marine Science, 2021
Coral reefs across the world are undergoing rapid deterioration, and understanding the ecological and evolutionary processes that govern these ecosystems is critical to our ability to protect them.
Pim Bongaerts, Pim Bongaerts, Caroline E. Dubé, Caroline E. Dubé, Katharine E. Prata, Katharine E. Prata, Johanna C. Gijsbers, Johanna C. Gijsbers, Michelle Achlatis, Michelle Achlatis, Michelle Achlatis, Alejandra Hernandez-Agreda   +11 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

bac-genomics-scripts: Bovine E. coli mastitis comparative genomics edition

, 2016
<p>This release of the <em>bac-genomics-scripts</em> serves as a supplement to a publication on comparative genomics of mastitis-associated and bovine commensal <em>Escherichia coli</em> isolates.</p> <p>https://
Andreas Leimbach (3161328), Andreas Leimbach   +1 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Functional Genomics for Plant Breeding 3.0

Functional genomics, as a scientific discipline, has significantly transformed the landscape of plant breeding in recent years [...
José Manuel Cruz-Rubio, Fatemeh Maghuly
core   +1 more source

Genomic landscape of intracranial meningiomas [PDF]

Journal of Neurosurgery, 2016
Meningiomas are the most common primary intracranial neoplasms in adults. Current histopathological grading schemes do not consistently predict their natural history. Classic cytogenetic studies have disclosed a progressive course of chromosomal aberrations, especially in high-grade meningiomas.
Wenya Linda, Bi, Malak, Abedalthagafi, Peleg, Horowitz, Pankaj K, Agarwalla, Yu, Mei, Ayal A, Aizer, Ryan, Brewster, Gavin P, Dunn, Ossama, Al-Mefty, Brian M, Alexander, Sandro, Santagata, Rameen, Beroukhim, Ian F, Dunn   +12 more
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Landscape Genomic Analyses of Quercus agrifolia Née Predict Patterns of Adaptedness to Future Climate and Provide Guidance for Conservation

Evolutionary Applications
Habitat destruction and climate change are two primary drivers of global biodiversity loss. Many contemporary ecological preserves and preserve networks are designed to protect species and the ecological and evolutionary processes that will maintain ...
Ryan C. Buck, H. Scott Butterfield, Elizabeth Hiroyasu, Jeanette Howard, John Knapp, Zachary Principe, Victoria L. Sork   +6 more
doaj   +1 more source