Results 81 to 90 of about 1,387,202 (292)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Decoding Genomic Landscapes of Introgression
Trends in GeneticsGenomic landscapes of introgression provide valuable information for how different evolutionary processes interact and leave signatures in genomes. The recent expansion of genomic datasets across diverse taxa, together with advances in methodological development, has created new opportunities to investigate the impact of introgression along individual ...
Xin Huang, Josef Hackl, Martin Kuhlwilm
openaire +3 more sources
The Genomic Landscape of Compensatory Evolution [PDF]
PLoS Biology, 2014 Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects through compensatory genetic changes.
Szamecz Béla +13 more
openaire +5 more sources
Evolutionary ApplicationsClimate change is the greatest challenge to modern agriculture. It significantly impacts agricultural systems through an increased frequency and intensity of extreme environmental events.
Alessandra Lezzi +6 more
doaj +1 more source
Generating continuous maps of genetic diversity using moving windows
Methods in Ecology and Evolution, 2023 Genetic diversity plays a key role in maintaining population viability by preventing inbreeding depression and providing the building blocks for adaptation.
Anusha P. Bishop +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Integrating very high resolution environmental proxies in genotype–environment association studies
Evolutionary ApplicationsLandscape genomic analyses associating genetic variation with environmental variables are powerful tools for studying molecular signatures of species' local adaptation and for detecting candidate genes under selection.
Annie S. Guillaume +5 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2019 The association between the African ant plant, Vachellia drepanolobium, and the ants that inhabit it has provided insight into the boundaries between mutualism and parasitism, the response of symbioses to environmental perturbations, and the ecology of ...
John H. Boyle +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Interpreting the genomic landscape of introgression
Current Opinion in Genetics & Development, 2017 Introgression, the transfer of genetic material between species through hybridisation, occurs in many taxa and has important consequences. Genomic studies allow us to characterise the landscape of introgression across the genome, shedding light on both its adaptive benefits and the incompatibilities that help to maintain species barriers.
Martin, Simon H, Jiggins, Chris D
openaire +2 more sources