Results 91 to 100 of about 226,550 (307)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Greenways as strategic landscape planning: theory and application
, 2002 Greenways are systems and/or networks of protected lands that are managed for multiple uses including: nature protection, biodiversity management, water resources, recreation, and cultural/historic resource protection.
Ahern, J.F.
core
Atmosphere, 2018 The motivation of this paper is that the effect of landscape pattern information on the accuracy of particulate matter estimation is seldom reported. The landscape pattern indexes were incorporated in a land use regression (LUR) model to investigate the ...
Shan Yang +4 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Renmin Zhujiang, 2020 Landscape pattern makes great influence on the water environment and water ecology of rivers and lakes.In recent years,it is a hot research direction for ecological assessment and restoration of rivers and lakes to reflect the environment and ecological ...
FANG Shenguang, JIANG Peixuan
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Spatiotemporal analysis of Indian megacities
, 2008 Urbanization is arguably the most dramatic form of highly irreversible land transformation. While urbanization is a worldwide phenomenon, it is exceptionally dynamic in India, where unprecedented urban growth rates have occurred over the last 30 years ...
Taubenböck, Hannes +5 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Landscape change and its effects on the visual experience of a case study area in the Öresunds region [PDF]
The study focuses on landscape change, from an historical perspective (year 1915) and as a discussion of future changes (year 2015) for a case study area in southern Sweden.
Åsa Ode
core
Plant Spatial Pattern Predicts Hillslope Runoff and Erosion in a Semiarid Mediterranean Landscape
, 2007 The importance of the spatial pattern of vegetation for hydrological behavior in semiarid environments is widely acknowledged. However, there is little empirical work testing the hypothetical covariation between vegetation spatial structure and hillslope
Bautista, Susana +4 more
core +1 more source