Results 91 to 100 of about 998,860 (301)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Potential impacts of changing agricultural activities on scenic beauty - a prototypical technique for automated rapid assessment [PDF]
, 2018 As a result of the liberalisation of the agricultural market, mountain regions in Central Europe are at great risk of experiencing increasing land abandonment and spontaneous reforestation.
Hunziker, Marcel, Kienast, Felix
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Spatio temporal landscape pattern change in rapid urbanization of Iskandar Malaysia [PDF]
, 2014 The urbanization process is continuously modifying the pattern of land use and land cover to support human development. Analyzing spatiotemporal land use change is essential for understanding its characteristic and ecological consequences.
Muhamad Ludin, Ahmad Nazri +2 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Renmin Zhujiang, 2020 Landscape pattern makes great influence on the water environment and water ecology of rivers and lakes.In recent years,it is a hot research direction for ecological assessment and restoration of rivers and lakes to reflect the environment and ecological ...
FANG Shenguang, JIANG Peixuan
doaj
Atmosphere, 2018 The motivation of this paper is that the effect of landscape pattern information on the accuracy of particulate matter estimation is seldom reported. The landscape pattern indexes were incorporated in a land use regression (LUR) model to investigate the ...
Shan Yang +4 more
doaj +1 more source
Using landscape history to predict biodiversity patterns in fragmented landscapes
Ecology Letters, 2013 AbstractLandscape ecology plays a vital role in understanding the impacts of land‐use change on biodiversity, but it is not a predictive discipline, lacking theoretical models that quantitatively predict biodiversity patterns from first principles. Here, we draw heavily on ideas from phylogenetics to fill this gap, basing our approach on the insight ...
Ewers, R.M. +7 more
openaire +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Beyond the stand: Reviewing landscape fragmentation dynamics on biodiversity and ecosystem services in Southeast Asia [PDF]
, 2019 Forest and agriculture landscapes dominate across Southeast Asia. Agricultural systems are highly diverse ranging from traditional swidden and agroforestry, to the more recent intensive industrial oil palm plantations.
Laumonier, Yves, Lo, M.
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