Results 111 to 120 of about 998,860 (301)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Impacts of spatio-temporal change of landscape patterns on habitat quality across Zayanderud Dam watershed in central Iran

Scientific Reports
The biodiversity of an ecosystem is greatly influenced by the spatio-temporal pattern of the landscape. Understanding how landscape type affects habitat quality (HQ) is important for maintaining environmental and ecological sustainability, preserving ...
Seyed Mohammad-reza Abolmaali, Mostafa Tarkesh, Seyed Alireza Mousavi, Hamidreza Karimzadeh, Saeid Pourmanafi, Sima Fakheran   +5 more
doaj   +1 more source

Building resilient communities in Belize through climate-smart agricultural practices [PDF]

, 2020
Indigenous communities have always coexisted with nature. Their subsistence has had a dependence on the heightened stewardship of the natural environment, requiring that their farming practices evolve and adapt to today’s rapidly changing environment. As
Garcia, Christina, Requena, Gustavo, Vasquez, Marvin   +2 more
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A landscape pattern gradient analysis method coupling wavelet algorithm for balancing development and protection activities of the coastal zone: A case study

Ecological Indicators
Due to the economic importance and ecological vulnerability of coastal areas, the optimization of spatial patterns is important for the sustainable development of coastal zones.
Xingpo Liu, Zixuan Yang, Yaozhi Chai
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Analysis of Landscape Pattern Evolution and Impact Factors in the Mainstream Basin of the Tarim River from 1980 to 2020

Hydrology
The mainstream basin of the Tarim River serves as a vital ecological security barrier that prevents the merging and expansion of deserts and an important strategic corridor directly linking Qinghai and Xinjiang.
Lili Jiang, Yating Li
doaj   +1 more source

The alternative uses of disused dairy factories in Taranaki : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Geography at Massey University [PDF]

, 1983
Small local dairy factories have long been a part of New Zealand's dairying heritage. No longer profitable in their original use, subsequent redundancy and abandonment has seen the appearance of the "disused dairy factory" in the rural landscape.
O'Donnell, Christine Anne
core