Results 131 to 140 of about 226,550 (307)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Does a Time-Lagged Effect Exist Between Landscape Pattern Changes and Giant Panda Density?

Land use and land cover change (LULCC) can influence giant panda distributions by altering landscape structure and configuration. However, the spatial impacts and potential time lag effects of landscape pattern changes on giant pandas remain ...
Qingxia Zhao, Jiqin Huang, Dong Chen, Qifeng Zhu, Yueduo Cui, Yutai Liu, Xuelin Jin   +6 more
core   +1 more source

Sensitivity of landscape measurements to changing grain size for fine-scale design and management

, 2007
Landscape pattern quantities are affected by issues of scale, namely extent and resolution. The grain size (resolution) of fine-resolution geographic information system (GIS) data for two highly fragmented landscapes in USA and Italy were altered to ...
Lafortezza, Raffaele, Corry, Robert C.
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Is There a Spatial Relationship between Urban Landscape Pattern and Habitat Quality? Implication for Landscape Planning of the Yellow River Basin. [PDF]

Int J Environ Res Public Health, 2022
Zhang D, Wang J, Wang Y, Xu L, Zheng L, Zhang B, Bi Y, Yang H.   +7 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Land use changes, landscape ecology and their socioeconomic driving forces in the Spanish Mediterranean coast (the Maresme County, 1850-2005)

We use a set of landscape metrics to study the long-term environmental transformation of a typical coastal Mediterranean area from 1850 to 2005. Our figures show a dramatic environmental deterioration between 1950 and 2005.
Lluis Parcerisas, Francesc Coll, Joan Marull, Enric Tello, Joan Pino, Corina Basnou   +5 more
core  

Feeling good and feeling safe in the landscape: a `syntactic' approach

, 2007
Space syntax is a theory and set of tools and techniques for the analysis of spatial configurations. It was developed at UCL in the late 1970s, as an approach to understanding human spatial organisation and to help architects and urban designers to ...
Hanson, Julienne, Dalton, Ruth
core  

Iceland as a Landscape Investigation Pattern

Nordicum-Mediterraneum, 2007
Nowadays Icelanders continue an ancient dialogue. Nature is part of their soul and they take with them bits of their terrestrial landscape when they move to the elsewhere.
Campanini, Manuela Silvia
doaj  

Landscape Pattern and Ecological Risk Assessment in Guangxi Based on Land Use Change. [PDF]

Int J Environ Res Public Health, 2022
Yang Y, Chen J, Lan Y, Zhou G, You H, Han X, Wang Y, Shi X.   +7 more
europepmc   +1 more source