Results 121 to 130 of about 226,550 (307)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Visibility graphs and landscape visibility analysis

, 2001
Visibility analysis based on viewsheds is one of the most frequently used GIS analysis tools. In this paper we present an approach to visibility analysis based on the visibility graph. A visibility graph records the pattern of mutual visibility relations
O'Sullivan, D, Turner, A
core  

Landscape Pattern and Ecological Risk Assessment in Guilin Based on Land Use Change. [PDF]

Int J Environ Res Public Health, 2023
Lan Y, Chen J, Yang Y, Ling M, You H, Han X.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Temporal and Spatial Changes of Soil Erosion and Its Response to Landscape Pattern in Dabie Mountains of Western Anhui in Recent 30 Years

Shuitu Baochi Xuebao
[Objective] The Dabie Mountain area in western Anhui Province is an important ecological transition area between the Yangtze River Basin and the Huaihe River Basin in Anhui Province.
TIAN Changyuan, ZHANG Hongli, WANG Junhong, LI Jianing, ZHANG Yi, ZHA Tonggang   +5 more
doaj   +1 more source

Landscape Pattern Change and Ecological Effect in a Typical Mountain-Oasis-Desert Region in the Northwest Region of China. [PDF]

Int J Environ Res Public Health, 2023
Meng H, Hu Y, Dong Z.
europepmc   +1 more source

Promoting sustainable landscape pattern for landscape sustainability [PDF]

Landscape Ecology, 2021
Peng, J., Liu, Y., Corstanje, R., Meersmans, Jeroen   +3 more
openaire   +2 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

The impacts of urban landscape pattern on urban land surface temperature - taking Urumqi as an example

, 2009
Urbanization has become an important contributor for global warming and urban air temperature is rising gradually in all the cities. It means that urban land use and land cover (LULC) changed became critical in determining the urban environment quality ...
Bao, Xi1, 2, Kurban, Wang, Alishir1, Shanshan1, Chen, An-Ming1   +8 more
core  

Multi-Scenario Simulation of Green Space Landscape Pattern in Harbin City Based on FLUS Model. [PDF]

Int J Environ Res Public Health, 2023
Li X, Li W, Gao Y.
europepmc   +1 more source