Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Study on Landscape Pattern Feature and Its Change in Jinsha River Watershed（Yunnan Part）
Shuitu baochi yanjiu, 2008 Jinsha river watershed is the ecologically fragile area in Chinese western region,and its vegetation was often disturbed by human.Through the study on patch size and change for all kinds of vegetation in this region,the effects from human disturbance can
XIA Ji-sheng1 +4 more
doaj
Study on land use and landscape pattern change in the Huaihe River Ecological and economic zone from 2000 to 2020. [PDF]
Heliyon, 2023 You M, Zou Z, Zhao W, Zhang W, Fu C.
europepmc +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Dynamic Analysis of Landuse Landscape Pattern in Mengyin County,Shandong Province
Shuitu baochi yanjiu, 2011 In order to understand the dynamic changes of landscape pattern characteristics,based on the 1987 and 2007 the typical period of two remote sensing images,we used the RegionManager 5.5,Arc GIS and other geographic information systems software in support ...
LI Huan1 +4 more
doaj
Is There a Spatial Relationship between Urban Landscape Pattern and Habitat Quality? Implication for Landscape Planning of the Yellow River Basin. [PDF]
Int J Environ Res Public Health, 2022 Zhang D +7 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Land use changes, landscape ecology and their socioeconomic driving forces in the Spanish Mediterranean coast (the Maresme County, 1850-2005) [PDF]
We use a set of landscape metrics to study the long-term environmental transformation of a typical coastal Mediterranean area from 1850 to 2005. Our figures show a dramatic environmental deterioration between 1950 and 2005.
Lluis Parcerisas +5 more
core
Landscape Pattern and Ecological Risk Assessment in Guangxi Based on Land Use Change. [PDF]
Int J Environ Res Public Health, 2022 Yang Y +7 more
europepmc +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source