Results 101 to 110 of about 998,860 (301)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Scientific ReportsEffective landscape management is vital for maximizing the availability of ecosystem service functions (ESF). However, how landscape pattern simultaneously affects multiple ESF across time and space, specifically regarding changes in their relationships,
Yao Yao, Yuanyuan Yang
doaj +1 more source
Cities and Satellites: Spatial Effects and Unobserved Heterogeneity in the Modeling of Urban Growth [PDF]
The confluence of factors driving urban growth is highly complex, resulting from a combination of ecological and social determinants that co-evolve over time and space.
Colin Vance, Rich Iovanna
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Renmin Zhujiang, 2020 Since the implementation of the policy of reform and opening up,the dramatic evolution of land use and landscape pattern in basins has been brought about by the rapid development of urbanization,threatening the health of its natural eco-hydrological ...
ZHU Zhenjie, YANG Zibo, LIU Bingjun
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Biochemical processes in sagebrush ecosystems: Interactions with terrain [PDF]
The objectives of a biogeochemical study of sagebrush ecosystems in Wyoming and their interactions with terrain are as follows: to describe the vegetational pattern on the landscape and elucidate controlling variables, to measure the soil properties and ...
Matson, P., Reiners, W., Strong, L.
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Geo-spatial Information ScienceIn the context of global regional economic integration and rapid urban expansion, the mutual promotion and coordinated development of regional economic linkages (REL) and landscape resource utilization have become the key to achieving the sustainability ...
Ku Gao +6 more
doaj +1 more source
Introducing Preference Heterogeneity into a Monocentric Urban Model: an Agent-Based Land Market Model [PDF]
, 2008 This paper presents an agent-based urban land market model. We first replace the centralized price determination mechanism of the monocentric urban market model with a series of bilateral trades distributed in space and time.
Filatova, Tatiana +2 more
core +1 more source