Results 101 to 110 of about 226,550 (307)

Spatiotemporal effects of landscape structure on the trade-offs and synergies among ecosystem service functions in Yangtze River Economic Belt, China

Scientific Reports
Effective landscape management is vital for maximizing the availability of ecosystem service functions (ESF). However, how landscape pattern simultaneously affects multiple ESF across time and space, specifically regarding changes in their relationships,
Yao Yao, Yuanyuan Yang
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Spatial-temporal coupling coordination patterns between regional economic linkages and fine landscape resources utilization: a case of the Greater Bay Area, China

Geo-spatial Information Science
In the context of global regional economic integration and rapid urban expansion, the mutual promotion and coordinated development of regional economic linkages (REL) and landscape resource utilization have become the key to achieving the sustainability ...
Ku Gao, Xiaomei Yang, Zhihua Wang, Yueming Liu, Huifang Zhang, Xiaowei Zeng, Qingyang Zhang   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Land use changes, landscape ecology and their socioeconomic driving forces in the Spanish Mediterranean coast (the Maresme County, 1850-2005)

, 2013
[cat] Utilitzem un conjunt de mètriques del paisatge per estudiar l'evolució a llarg termini seguida en una típica zona costanera del Mediterrani des de 1850 fins a 2005, que mostren una greu deterioració del medi ambient entre 1950 i 2005.
Marull, Joan, Pino i Vilalta, Joan, Parcerisas i Benedé, Lluís, 1978-, Coll, Francesc, Tello, Enric, Basnou, Corina   +5 more
core  

Analysis of Spatio-temporal Evolution of Land Use and Landscape Pattern in Liuxi River Basin Driven by Rapid Urbanization

Renmin Zhujiang, 2020
Since the implementation of the policy of reform and opening up,the dramatic evolution of land use and landscape pattern in basins has been brought about by the rapid development of urbanization,threatening the health of its natural eco-hydrological ...
ZHU Zhenjie, YANG Zibo, LIU Bingjun
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Landscape genetics of highly disturbed arable systems : insights gained from investigating a small mammal species

, 2015
A large proportion of the earth’s surface is dedicated to food production, and agriculture is widely acknowledged to influence local biodiversity via habitat loss and degradation.
Wilson, Amanda
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

How do Changes in Land Use Patterns Affect Species Diversity? an Approach for Optimizing Landscape Configuration [PDF]

Heterogeneity of agricultural landscapes is supposed to be of significant importance for species diversity in agroecosystems (Weibull et al. 2003). Thus it is necessary to account for structural aspects of landscapes in land management decision processes.
Ralf Seppelt, Angela Lausch, Annelie Holzkamper   +2 more
core