Results 81 to 90 of about 226,550 (307)
, 2021 The impact of human interference on the ecological environment has attracted a significant amount of attention. In this study, hemeroby index (HI) was constructed to quantify the degree of human disturbance, and the relationship between HI and landscape ...
Jianzhen Zhang +6 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Applying Landscape Ecological Metrics on Land Use Change in Lanyang Plain [PDF]
Land use is the human activity affecting by economical, cultural, political and historical factors and presents complex, uncertainty and spatiotemporal characteristics.
Hsiao-Wen Wang
core
, 2003 Semi-natural grasslands in Sweden are threatened by land-use change and lack of management with attendant risk to their biodiversity. We present a model to explore the effects of grazing frequency and intensity on plant species persistence, and the ...
Lavorel, Sandra, +2 more
core +1 more source
, 2022 The coupling between land use/landscape pattern and water quality in river systems varies across different spatial and temporal scales. It is important to understand the association between water quality and land use/landscape pattern across different ...
Zhang, Quanfa +11 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Landscape pattern and process of modern oasis in Xinjiang, China
, 2007 Based on Landsat MSS/TM images and CBERS-02 CCD data of Beitun Oasis in Ertix River Watershed in the years of 1972, 1989, 1999 and 2005, the landscape patterns for the past 30 years were analyzed. Using the GIS data collective platform, we calculated the
Huang +14 more
core
Using landscape history to predict biodiversity patterns in fragmented landscapes
Ecology Letters, 2013 AbstractLandscape ecology plays a vital role in understanding the impacts of land‐use change on biodiversity, but it is not a predictive discipline, lacking theoretical models that quantitatively predict biodiversity patterns from first principles. Here, we draw heavily on ideas from phylogenetics to fill this gap, basing our approach on the insight ...
Ewers, R.M. +7 more
openaire +4 more sources