Results 91 to 100 of about 2,063,143 (381)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Landscapes and landscape research in Germany

Belgeo, 2004
Landscape research has a long tradition in Germany. After Alexander von Humboldt introduced the term «landscape» 200 years ago, as the «total character of a region» (Totalcharakter von Erdgegenden), it became a key focus of study for Geography ...
Marion Potschin, Olaf Bastian
doaj   +1 more source

Conserving California Landscapes: Midterm Report [PDF]

, 2000
Provides a review at the halfway point of a program that was designed to conserve large expanses of open space, farmlands, and wildlife habitat in three California regions: the Central Coast, the Central Valley, and the Sierra ...

core  

Funnels in Energy Landscapes

, 2007
Local minima and the saddle points separating them in the energy landscape are known to dominate the dynamics of biopolymer folding. Here we introduce a notion of a "folding funnel" that is concisely defined in terms of energy minima and saddle points ...
Becker, Bryngelson, C. Flamm, Doye, Fain, Flamm, Flamm, Flamm, Galzitskaya, Garstecki, Hofacker, K. Klemm, Leopold, Mertens, Okazaki, Onuchic, Onuchic, Onuchic, P. F. Stadler, Wales, Wolfinger, Wuchty   +21 more
core   +3 more sources

Flaubert’s Landscapes

Compendium : Journal of Comparative Studies = Revista de Estudos Comparatistas, 2022
From the Archive is a special section of Compendium dedicated to republishing texts from the Centre for Comparative Studies’ two-decade history of academic publishing in book form, giving them a new visibility and easier international outreach online. The choice of book chapters and articles to include in this section is based on the way they directly ...
openaire   +2 more sources

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer [PDF]

, 2020
Anthony R. Cillo, Cornelius Kürten, Tracy Tabib, Zengbiao Qi, Sayali Onkar, Ting Wang, Angen Liu, Umamaheswar Duvvuri, Seungwon Kim, Ryan J. Soose, Steffi Oesterreich, Wei Chen, Robert Lafyatis, Tullia C. Bruno, Robert L. Ferris, Dario A.A. Vignali   +15 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Rewilding soil and litter invertebrates and fungi increases decomposition rates and alters detritivore communities

Ecology and Evolution
Habitat degradation and associated reductions in ecosystem functions can be reversed by reintroducing or ‘rewilding’ keystone species. Rewilding projects have historically targeted restoration of processes such as grazing regimes or top‐down predation ...
Peter Contos, Nicholas P. Murphy, Zachary J. Kayll, Tamara Morgan, Joshua J. Vido, Orsi Decker, Heloise Gibb   +6 more
doaj   +1 more source

Winds of Change: Urgent Challenges and Emerging Opportunities in Submerged Prehistory, a Perspective from the North Sea

Heritage
Development of the continental shelf has accelerated significantly as nations around the world seek to harness offshore renewable energy. Many areas marked for development align with submerged palaeolandscapes. Poorly understood and difficult to protect,
Vincent Gaffney, Rachel Harding, Simon Fitch, James Walker, Victoria Boothby, Andrew Iain Fraser   +5 more
doaj   +1 more source

De part et d’autre du Rhin. Descriptions géographiques et représentations nationales dans les Causeries du voyage franco-allemand de Victor Duruy (1860)

Belgeo, 2013
French Historian Victor Duruy’s 1860 travel on Rhine and Danube gives him rise to go all over South of Germany. He let a diary of this journey, original in terms of both content and form. His geographical and ethnographical observations allow him to make
Jean-Charles Geslot
doaj   +1 more source