Results 101 to 110 of about 133,287 (310)

Taking the Punishment Out of the Process: From Substantive Criminal Justice Through Procedural Justice to Restorative Justice [PDF]

, 2004
If the punishment is taken out of the process, and the processes of criminal justice become effective at restoration--and if rigorous empirical research might show that a restorative process costs less money and produces greater public safety--that would
Blackwell, Brenda Sims, Cunningham, Clark D.   +1 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Teaching Chang-rae Lee’s _Aloft_: Exploring the Limits of Race and Ethnicity [PDF]

, 2012
Chang-rae Lees 2004 novel Aloft may not be his most famous work, but it is a highly effective classroom text. In its contemporary, multicultural, suburban setting, it portrays a world that students recognize; simultaneously, however, it can effectively ...
Cleland, Jaime
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Towards a breakthrough in nutrient recycling : State-of-the-art and recommendations for developing policy instruments in Finland [PDF]

, 2018
The report has been complemented on 11.9.2018This report describes the state-of-the-art in phosphorus and nitrogen recycling in Finland and looks at basic data on the volumes and geographical distribution of biomasses and their nutrients.
Grönroos, Juha, Iho, Antti, Kauppila, Jussi, Koikkalainen, Kauko, Koskiaho, Jari, Laine-Ylijoki, Jutta, Lantto, Raija, Lehtonen, Eeva, Luostarinen, Sari, Marttinen, Sanna, Oasmaa, Anja, Rasa, Kimmo, Sarvi, Minna, Tampio, Elina, Turtola, Eila, Valve, Helena, Venelampi, Olli, Ylivainio, Kari, zu Castell-Rüdenhausen, Malin   +18 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Barriers to English Language Learners in the Chicago Metropolitan Area [PDF]

, 2001
Immigrants from all over the world are continuing to move to Illinois in large numbers. As they settle into an increasingly diverse range of communities within metropolitan Chicago, this expansion of ports of entry creates new challenges for the state ...
Jody Raphael, Lise McKean, Melissa Ford
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

How the Seneca Gaming Corporation has Violated its Contract and Broken Its Promises to the City of Buffalo [PDF]

, 2013
The Seneca Gaming Corporation promised the City of Buffalo, in a legally binding contract, that it would construct a tourist destination casino in a park-like setting, market it to out-of-town visitors, and employ large numbers of Buffalonians.
LoCurto, Michael
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source