Results 41 to 50 of about 1,841,934 (257)

Thermal Feedback for Simulated Lane Change Scenarios [PDF]

International Journal of Mobile Human Computer Interaction, 2019
Most research into haptic feedback for in-car applications has used vibrotactile feedback. In this article, two simulator studies investigate novel thermal feedback during driving for a lane change task. The distraction and time differences of audio and thermal feedback were investigated in the first, with results showing that thermal feedback does not
Di Campli San Vito, Patrizia, Brewster, Stephen, Pollick, Frank, White, Stuart, Skrypchuk, Lee, Mouzakitis, Alexandros   +5 more
openaire   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Research on Mandatory Lane-Changing Behavior in Highway Weaving Sections

Journal of Advanced Transportation, 2020
As the accident-prone sections and bottlenecks, highway weaving sections will become more complicated when it comes to the mixed-traffic environments with connected and automated vehicles (CAVs) and human-driven vehicles (HVs).
Wei Hao, Zhaolei Zhang, Zhibo Gao, Kefu Yi, Li Liu, Jie Wang   +5 more
doaj   +1 more source

Influencing Factors of the Length of Lane-Changing Buffer Zone for Autonomous Driving Dedicated Lanes

Applied Sciences, 2022
With the development of intelligent transportation, dedicated highway lanes for autonomous vehicles (AVs), necessary for ensuring their right of way, have emerged as critical issues in intelligent transportation research, which makes it necessary to set ...
Fujin Hou, Ying Zhang, Shujian Wang, Zhengxi Shen, Peipei Mao, Xu Qu   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A state dependent mandatory lane-changing model for urban arterials with hidden markov model method

International Journal of Transportation Science and Technology, 2019
The inherent intention and decision process of lane changes are complex. Though the external environment and traffic conditions are changing along the traveling direction, the drivers’ characteristics and preferences may lead to persistence of preferable
Xiduo Wang, Yunlong Zhang, Jian Jiao
doaj   +1 more source

Planning flexible and smooth paths for lane‐changing manoeuvres of autonomous vehicles

IET Intelligent Transport Systems, 2021
Lane‐changing manoeuvres are essential for daily driving tasks. Safety and comfort are the primary issues to be considered during the lane‐changing manoeuvres of autonomous vehicles. However, because the traffic environment is complicated and changeable,
Bo Zhang, Jianwei Zhang, Yang Liu, Konghui Guo, Haitao Ding   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Lane County Public Health Authority Comprehensive Plan [PDF]

, 2010
71 pp. Charts, tables.The Comprehensive Plan submitted for FY 2010-2011 for Lane County includes the following narrative sections: an assessment which provides demographic and public health indicators for Lane County; a description of the delivery of ...
Lane County (Or.)
core   +1 more source