Results 41 to 50 of about 54,115 (209)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Modeling collision risk for unsafe lane-changing behavior: A lane-changing risk index approach

Alexandria Engineering Journal
The lane-changing maneuvers are challenging and contributes to traffic accidents and crashes. They are complicated task that often lead to an increased risk of vehicle collisions and deteriorates traffic flow. This paper proposes a vehicle collision risk
Muhammad Sameer Sheikh, Yinqiao Peng
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Exploring Sustainable Lane-Change Behaviours – Integrated Approach to Modelling Mixed Traffic with Intelligent-Connected Vehicles

Promet (Zagreb)
This paper proposes two sustainable lane-changing (LC) decision-making models for application in intelligent-connected (I-C) and mixed-traffic environments.
Xushan FANG, Peikun LIAN, Wei HUANG, Chao WANG, Said M. EASA, Shuang LIN, Ning CHEN   +6 more
doaj   +1 more source

Research on Decision-Making Behavior of Discretionary Lane-Changing Based on Cumulative Prospect Theory

Journal of Advanced Transportation, 2020
In this paper, the decision-making model of discretionary lane-changing is established using cumulative prospect theory (CPT). Through analyzing the vehicles’ dynamic running states, safety spacing calculating approaches for discretionary lane-changing ...
Xueqin Long, Liancai Zhang, Shanshan Liu, Jianjun Wang   +3 more
doaj   +1 more source

End-to-End Automated Lane-Change Maneuvering Considering Driving Style Using a Deep Deterministic Policy Gradient Algorithm

Sensors, 2020
Changing lanes while driving requires coordinating the lateral and longitudinal controls of a vehicle, considering its running state and the surrounding environment.
Hongyu Hu, Ziyang Lu, Qi Wang, Chengyuan Zheng   +3 more
doaj   +1 more source

A Novel Dynamic Lane-Changing Trajectory Planning Model for Automated Vehicles Based on Reinforcement Learning

Journal of Advanced Transportation, 2022
Lane changing behavior has a significant impact on traffic efficiency and may lead to traffic delays or even accidents. It is important to plan a safe and efficient lane-changing trajectory that coordinates with the surrounding environment.
Cenxin Yu, Anning Ni, Jing Luo, Jinghui Wang, Chunqin Zhang, Qinqin Chen, Yifeng Tu   +6 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Deep Q‐network based multi‐layer safety lane changing strategy for vehicle platoon

IET Intelligent Transport Systems
The vehicle platoon lane changing is significant for alleviating road congestion and diminishing transportation energy consumption. However, the lane changing strategy for a group of vehicles is still a great challenge in this field.
Jinqi Zhang, Maode Yan, Lei Zuo
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source