Results 21 to 30 of about 773 (166)

VISSIM-Based Simulation and Analysis of Upstream Segments in Ramp Areas for Optimizing Vehicle Group Lane-Changing Behaviors

Journal of Advanced Transportation, 2020
The traffic congestion in ramp areas is becoming increasingly prominent. In the upstream segments of ramp areas, effective management and control of lane-changing behaviors can improve the road capacity and make full use of the existing road resource ...
Haijian Li, Zhufei Huang, Xiaofang Zou, Shuo Zheng, Yanfang Yang   +4 more
doaj   +1 more source

Capturing Drivers’ Lane Changing Behaviors on Operational Level by Data Driven Methods

IEEE Access, 2018
With the development of autonomous vehicles, advanced driver-assistance systems, and vehicular social networks, the requirement for vehicle trajectory prediction in lane changing is higher.
Ling Huang, Hengcong Guo, Ronghui Zhang, Haiwei Wang, Jianping Wu   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Mathematical Modeling and Parameter Estimation of Lane-Changing Vehicle Behavior Decisions

Mathematics
Lane changing is a crucial scenario in traffic environments, and accurately recognizing and predicting lane-changing behavior is essential for ensuring the safety of both autonomous vehicles and drivers.
Jianghui Wen, Yebei Xu, Min Dai, Nengchao Lyu   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Active Lane-Changing Control of Intelligent Vehicle on Curved Section of Expressway

Modelling and Simulation in Engineering, 2022
In order to improve the intelligent vehicle lane-changing performance, an active lane-changing control algorithm is proposed considering the changes of road curvature and vehicle speed.
Pengfei Feng, Huiqing Jin, Linfeng Zhao, Mingyu Lu   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Target Vehicle Selection Algorithm for Adaptive Cruise Control Based on Lane-changing Intention of Preceding Vehicle

Chinese Journal of Mechanical Engineering, 2021
To improve the ride comfort and safety of a traditional adaptive cruise control (ACC) system when the preceding vehicle changes lanes, it proposes a target vehicle selection algorithm based on the prediction of the lane-changing intention for the ...
Jun Yao, Guoying Chen, Zhenhai Gao
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source