Results 111 to 120 of about 6,181,214 (306)

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang   +11 more
wiley   +1 more source

Lane County Notice of Adopted Amendment (2010-05-26)

open access: yes, 2010
24 pp. Adopted 2010-05-26. Department of Land Conservation and Development Notice of Adopted AmendmentA minor plan amendment to the Lane County Rural Comprehensive Plan to redesignate 1.55 acres of a 10.29 acre parcel from Agriculture Lane to Rural ...
Lane County (Or.)
core  

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

open access: yesAdvanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang   +12 more
wiley   +1 more source

Letter: William J. Lane to Ida M. Tarbell, August 10, 1897

open access: yes, 1897
Handwritten letter, 9 ...
Lane, William J.
core  

Lane Collection - John Lane House in Oldwick, circa 1910

open access: yes, 1910
This house in Oldwick was the home of John Lane, father of Ernest Lane and grandfather of Edythe Lane, who took this photograph circa ...

core   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

open access: yesAdvanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen   +19 more
wiley   +1 more source

Optimizing speed change lane lengths for two-way ten-lane expressways: a VISSIM and SSAM simulation-based approach

open access: yesScientific Reports
With rapid economic development, expressway traffic volumes have surged, resulting in severe congestion. To address this, expanding expressways to two-way ten-lane configurations has become a primary strategy for alleviating traffic pressure.
Dan Xiong, Quan Yu, Huihui Guo
doaj   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

open access: yesAdvanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon   +27 more
wiley   +1 more source

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