Results 131 to 140 of about 1,897,464 (299)

Macroscopic Characteristics of Lane-Changing Traffic

open access: yes, 2010
On a multilane roadway, systematic lane changes can seriously disrupt traffic flow and cause capacity reductions. Therefore it is important to understand the characteristics of lane-changing traffic flow.
Wen-Long Jin
core   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

open access: yesAdvanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu   +9 more
wiley   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

open access: yesAdvanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye   +9 more
wiley   +1 more source

Lane County ryegrass straw conversion to renewable energy and biofuel production project/feasibility study

open access: yes, 2008
Lane County received $250,000 from the Field Burning Research Fund for a short-term research project to identify near-term viable options for adding economic value to Annual Ryegrass Straw (ARS) through renewable energy and fuel production.

core  

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

open access: yesAdvanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su   +14 more
wiley   +1 more source

Lane Changing Control of Autonomous Vehicle With Integrated Trajectory Planning Based on Stackelberg Game

open access: yesIEEE Open Journal of Intelligent Transportation Systems
Lane changing present a significant challenge for autonomous vehicles, as they must maintain safe driving and optimize time efficiency. This process is strongly affected by traffic environment and driver characteristics.
Dongmei Wu   +5 more
doaj   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

open access: yesAdvanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan   +10 more
wiley   +1 more source

Assessment of Significant Factors Affecting Frequent Lane-Changing Related to Road Safety: An Integrated Approach of the AHP-BWM Model. [PDF]

open access: yesInt J Environ Res Public Health, 2021
Farooq D   +6 more
europepmc   +1 more source

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