Results 51 to 60 of about 7,145,619 (284)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ST-LaneNet: Lane Line Detection Method Based on Swin Transformer and LaneNet

Chinese Journal of Mechanical Engineering
The advancement of autonomous driving heavily relies on the ability to accurate lane lines detection. As deep learning and computer vision technologies evolve, a variety of deep learning-based methods for lane line detection have been proposed by ...
Yufeng Du, Rongyun Zhang, Peicheng Shi, Linfeng Zhao, Bin Zhang, Yaming Liu   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Lane Detection Method Based on RepVGG [PDF]

Jisuanji kexue
Aiming at the problems of slow detection speed and low detection accuracy in existing lane detection methods,lane detection is regarded as a classification problem,and a lane detection method based on RepVGG is proposed.Based on the RepVGG model ...
CAI Wenliang, HUANG Jun
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Enhancing Autonomous Vehicle Navigation by Detecting Lane and Objects based on LaneNet and CustomYOLOv5

Promet (Zagreb)
Lane and object detection are the major concerns of an autonomous vehicle’s ability to move continuously without creating any traffic congestion or collisions.
Jayamani SIDDAIYAN, Kumar PONNUSAMY
doaj   +1 more source

Lane-change detection based on individual driving style

, 2019
This paper presents a novel method to detect when a vehicle is changing lanes by considering individual driving styles. Some previous works have focused on the relation between lane changes and driving styles; however, the detection method of lane ...
Yusuke Tamura (2254126), Hajime Asama (727254), Yonghoon Ji (7332539), Hanwool Woo (7332536), Yasuhide Kuroda (7332542), Takashi Sugano (7332545), Yasunori Yamamoto (34512), Atsushi Yamashita (283413)   +7 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Grid Anchor Lane Detection Based on Attribute Correlation

Applied Sciences
The detection of road features is a necessary approach to achieve autonomous driving. And lane lines are important two-dimensional features on roads, which are crucial for achieving autonomous driving. Currently, research on lane detection mainly focuses
Qiaohui Feng, Cheng Chi, Fei Chen, Jianhao Shen, Gang Xu, Huajie Wen   +5 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source