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Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis
The Lancet, 1994X-chromosome-inactivation assays can be used to assess clonality. We used such an assay at the human androgen-receptor gene locus in three female patients with histologically proven Langerhans cell histiocytosis. All patients were heterozygous for this locus.
R C, Yu, C, Chu, L, Buluwela, A C, Chu
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Biology of Langerhans Cells and Langerhans Cell Histiocytosis
International Review of Cytology, 2006Langerhans cells (LC) are epidermal dendritic cells (DC). They play an important role in the initiation of immune responses through antigen uptake, processing, and presentation to T cells. Langerhans cell histiocytosis (LCH) is a rare disease in which accumulation of cells with LC characteristics (LCH cells) occur. LCH lesions are further characterized
G I, Bechan, R M, Egeler, R J, Arceci
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Langerhans' cell histiocytosis cells are activated langerhans' cells
The Journal of Pathology, 1994AbstractLangerhans' cell histiocytosis (LCH) is characterized by the presence of large mononucleated cells, associated with inflammatory cells. The Langerhans' cell (LC) lineage of the mononucleated cells is suggested by the presence of Birbeck granules and the expression of CD1a.
J F, Emile +4 more
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Clinical and Translational Oncology, 2008
Langerhans cell histiocytosis (LCH) is a poorly understood proliferative disease, with different patterns of clinical presentation. Currently it is classified according to the number and type of system involved and the degree of organ dysfunction. The aetiology of the disease remains uncertain, and in some cases the disease is polyclonal, suggesting a ...
Joan Manel, Gasent Blesa +6 more
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Langerhans cell histiocytosis (LCH) is a poorly understood proliferative disease, with different patterns of clinical presentation. Currently it is classified according to the number and type of system involved and the degree of organ dysfunction. The aetiology of the disease remains uncertain, and in some cases the disease is polyclonal, suggesting a ...
Joan Manel, Gasent Blesa +6 more
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Allergy, 1989
The morphological, enzymatical, immunocytochemical and functional properties of Langerhans' cells are briefly reviewed. Langerhans' cells are located mainly in the squamous stratified epithelia, but are also present in the thymus and in superficial lymphnodes.
RUCO, Luigi +2 more
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The morphological, enzymatical, immunocytochemical and functional properties of Langerhans' cells are briefly reviewed. Langerhans' cells are located mainly in the squamous stratified epithelia, but are also present in the thymus and in superficial lymphnodes.
RUCO, Luigi +2 more
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Differentiation of Langerhans cells in Langerhans cell histiocytosis
Blood, 2001Langerhans cell histiocytosis (LCH) consists of lesions composed of cells with a dendritic Langerhans cell (LC) phenotype. The clinical course of LCH ranges from spontaneous resolution to a chronic and sometimes lethal disease. We studied 25 patients with various clinical forms of the disease.
F, Geissmann +8 more
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Dermatology, 2009
Langerhans cell histiocytosis is a rare disease. Depending on which organs are involved, the disease may prove rapidly fatal, develop a chronic reactivating but therapy-responsive pattern or resolve spontaneously. Understanding of the pathology of the disease is progressing rapidly, and while clinical trials of standard chemotherapy agents continue, it
K, Windebank, V, Nanduri
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Langerhans cell histiocytosis is a rare disease. Depending on which organs are involved, the disease may prove rapidly fatal, develop a chronic reactivating but therapy-responsive pattern or resolve spontaneously. Understanding of the pathology of the disease is progressing rapidly, and while clinical trials of standard chemotherapy agents continue, it
K, Windebank, V, Nanduri
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Neuropeptides and Langerhans cells
Experimental Dermatology, 1998Abstract: The immune system and nervous system are intimately related. In addition to neuroendocrine mechanisms, neuropeptides have a variety of effects on immune cells and are responsible at least in part for neurogenic inflammation. The presence of neuropeptides in the skin has been well documented. The influence of neuropeptides on Langerhans cells
R W, Lambert, R D, Granstein
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Langerhans’ Cell Histiocytosis
Orthopedic Clinics of North America, 1996Langerhans' Cell Histiocytosis, formerly known as Histiocytosis X, and its related syndromes (i.e., eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease) are briefly reviewed. The biology, clinical manifestations, and treatment options of the localized, single form and the disseminated, multisystem form are also discussed.
M C, Velez-Yanguas, R P, Warrier
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