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The Langerhans cell

Journal of the American Academy of Dermatology, 1982
Langerhans cells (LCs) function as the most peripheral outpost of the immune system. Although first identified in the skin, these cells probably originate in the bone marrow and migrate actively between the epidermis and the lymph nodes. They appear to play a critical role in immune surveillance and the development of contact allergy. The importance of
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Langerhans cell histiocytosis

Australasian Journal of Dermatology, 2001
SUMMARYLangerhans cell histiocytosis is a rare condition that can affect any organ of the body. Patients of all ages may present to the dermatologist and it is important to make the diagnosis as quickly as possible, because time from presentation to diagnosis is of prognostic importance in adults with the disease.
K S, Caldemeyer   +2 more
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The Cell of Langerhans

1965
Publisher Summary Langerhans cells are interspersed among keratinocytes which form the “perpetually transient population of the more superficial layers of the epidermis”. They are themselves, therefore, presumably “transients” which continually need replacing.
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Langerhans cell histiocytosis

The Journal of Pediatrics, 1995
The first major stride toward understanding LCH was taken when ultrastructural studies identified the proliferating cells as part of the Langerhans (dendritic) cell system. Another step forward was the definition of the morphologic, immunohistochemical, and clinical criteria needed for the diagnosis of LCH.
R M, Egeler, G J, D'Angio
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Viruses and Langerhans cells

Immunology & Cell Biology, 2010
Langerhans cells (LCs) are the resident dendritic cells (DCs) of epidermis in human mucosal stratified squamous epithelium and the skin. A phenotypically similar DC has recently been discovered as a minor population in the murine dermis. In epidermis, LCs function as sentinel antigen‐presenting cells that can capture invading viruses such as herpes ...
Anthony L, Cunningham   +4 more
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Langerhans Cell Histiocytosis

New England Journal of Medicine, 1987
Nearly a century has passed since Alfred Hand reported a case of "polyuria and tuberculosis,"1 later considered to be the first case of the Hand-Schul1er–Christian syndrome.
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Langerhans' cell histiocytosis

The Lancet, 2005
A 38-year-old woman complained of persistent chest pain. A plain radiograph showed an irregularity on the sternum, and bone-scan showed uptake only in that area. Thoracic-abdominal CT showed an osteolytic lesion of the sternum (figure) without any other signs of neoplasia.
N. Fazio   +4 more
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Langerhans Cell Sarcoma

The American Journal of Dermatopathology, 2006
Proliferations of Langerhans cells can be histologically divided into cytologically benign Langerhans cell proliferations, which include the clinical syndromes of Langerhans cell histiocytosis, and cytologically malignant Langerhans cell sarcoma. We report a Langerhans cell sarcoma in a 33-year-old male that arose on the posterior thigh with subsequent
Tammie, Ferringer   +2 more
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Langerhans' cells histiocytosis.

International journal of pediatric otorhinolaryngology, 1999
Langerhans cell histiocytosis (LCH) is a rare disorder of unknown cause, characterized by the proliferation of histiocytic cells in various tissues and organs. The role of the otolaryngologist is important in the early and accurate evaluation, staging and diagnosis of LCH, because it may mimic more common diseases such as otitis externa and acute ...
SELLARI FRANCESCHINI, STEFANO   +5 more
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