Neutrophils in the Bone Marrow Express DEC205, Guiding Their Migration to Inflamed Tissues
Immunology, EarlyView.In bone marrow, immature neutrophils express high levels of DEC205, necessary to mediate migration through endothelial cell layers in vitro and in vivo. During maturation and migration to peripheral tissues, expression of DEC205 is downregulated. Thus, expression of DEC205 inversely correlates with the maturation of neutrophils and is involved in ...
Shiying Jin +4 more
wiley +1 more source
Membrane permeabilization by Islet Amyloid Polypeptide
, 2009 Membrane permeabilization by Islet Amyloid Polypeptide (IAPP) is suggested to be the main mechanism for IAPP-induced cytotoxicity and death of insulin-producing -cells in type 2 diabetes mellitus (T2DM).
Engel, Maarten F.M.
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Immunofluorescent Detection of Human B Cell Alloantigens on S-Ig-Positive Lymphocytes and Epidermal Langerhans Cells [PDF]
, 1978 Georg Stingl +3 more
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Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects
Immunology, EarlyView.The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder +4 more
wiley +1 more source
Pulmonary langerhans cell granulomatosis (histiocytosis X)
Туберкулез и болезни лёгких, 2014 Pulmonary Langerhans cell granulomatosis is a rare disease. Its causes are unknown and accurate data on its prevalence are lacking. This disease is characterized by the formation of lung tissue granulomas consisting of activated Langerhans cells ...
A. A. Sadovnikov, K. I. Panchenko
doaj
Plastics in dermatology: A review and solutions
Journal of the European Academy of Dermatology and Venereology, EarlyView.This review explores the environmental and health impacts of plastics, particularly microplastics in dermatological products. It discusses the plastic life cycle, routes of exposure, health risks and provides science‐based recommendations to reduce plastic use in dermatology.
Eugene Tan, Susanne Saha, Dennis Niebel
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Journal of the European Academy of Dermatology and Venereology, EarlyView.This study identifies interferons as key mediators in lichenoid chronic GVHD pathogenesis, along with Th2 and Th17 involvement. It particularly highlights the role of Type I interferon, showing that early anti‐IFNAR1 treatment reduces skin inflammation in a murine model of chronic cutaneous GVHD.
Chloé Grolleau +11 more
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B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. [PDF]
, 1994 Dendritic cells comprise a system of highly efficient antigen-presenting cells involved in the initiation of T cell responses. Herein, we investigated the role of the CD28 pathway during alloreactive T cell proliferation induced by dendritic-Langerhans ...
Azuma, M +6 more
core
ULTRASTRUCTURE OF THE A-CELLS OF CAT ISLETS OF LANGERHANS FOLLOWING SYMPATHETIC STIMULATION OF GLUCAGON SECRETION [PDF]
, 1970 A. C. Esterhuizen, Simon L. Howell
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Novel report of an osteogenic tumor in a late Jurassic Mamenchisaurid from Thailand
Journal of Anatomy, EarlyView.Here we describe a pathology in an ulna of a Late Jurassic mamenchisaurid from Thailand. We use anatomical descriptions, CT scanning, and bone histology to identify the pathology as an osteogenic tumor. Abstract Here we report on an osseous abnormality and multiple fractures in an ulna of a subadult basal Eusauropod (Mamenchisauridae) from the Late ...
Siripat Kaikaew +2 more
wiley +1 more source