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Langerhans' cell histiocytosis
The Lancet, 2005A 38-year-old woman complained of persistent chest pain. A plain radiograph showed an irregularity on the sternum, and bone-scan showed uptake only in that area. Thoracic-abdominal CT showed an osteolytic lesion of the sternum (figure) without any other signs of neoplasia.
N. Fazio +4 more
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Journal of the American Academy of Dermatology, 1982
Langerhans cells (LCs) function as the most peripheral outpost of the immune system. Although first identified in the skin, these cells probably originate in the bone marrow and migrate actively between the epidermis and the lymph nodes. They appear to play a critical role in immune surveillance and the development of contact allergy. The importance of
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Langerhans cells (LCs) function as the most peripheral outpost of the immune system. Although first identified in the skin, these cells probably originate in the bone marrow and migrate actively between the epidermis and the lymph nodes. They appear to play a critical role in immune surveillance and the development of contact allergy. The importance of
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Biology of Langerhans Cells and Langerhans Cell Histiocytosis
2006Langerhans cells (LC) are epidermal dendritic cells (DC). They play an important role in the initiation of immune responses through antigen uptake, processing, and presentation to T cells. Langerhans cell histiocytosis (LCH) is a rare disease in which accumulation of cells with LC characteristics (LCH cells) occur. LCH lesions are further characterized
Robert J. Arceci, G I Bechan, R M Egeler
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Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis
The Lancet, 1994X-chromosome-inactivation assays can be used to assess clonality. We used such an assay at the human androgen-receptor gene locus in three female patients with histologically proven Langerhans cell histiocytosis. All patients were heterozygous for this locus.
C. Chu +3 more
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Immunology & Cell Biology, 2010
Langerhans cells (LCs) are the resident dendritic cells (DCs) of epidermis in human mucosal stratified squamous epithelium and the skin. A phenotypically similar DC has recently been discovered as a minor population in the murine dermis. In epidermis, LCs function as sentinel antigen‐presenting cells that can capture invading viruses such as herpes ...
Najla Nasr +8 more
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Langerhans cells (LCs) are the resident dendritic cells (DCs) of epidermis in human mucosal stratified squamous epithelium and the skin. A phenotypically similar DC has recently been discovered as a minor population in the murine dermis. In epidermis, LCs function as sentinel antigen‐presenting cells that can capture invading viruses such as herpes ...
Najla Nasr +8 more
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1965
Publisher Summary Langerhans cells are interspersed among keratinocytes which form the “perpetually transient population of the more superficial layers of the epidermis”. They are themselves, therefore, presumably “transients” which continually need replacing.
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Publisher Summary Langerhans cells are interspersed among keratinocytes which form the “perpetually transient population of the more superficial layers of the epidermis”. They are themselves, therefore, presumably “transients” which continually need replacing.
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The American Journal of Dermatopathology, 2006
Proliferations of Langerhans cells can be histologically divided into cytologically benign Langerhans cell proliferations, which include the clinical syndromes of Langerhans cell histiocytosis, and cytologically malignant Langerhans cell sarcoma. We report a Langerhans cell sarcoma in a 33-year-old male that arose on the posterior thigh with subsequent
John S. Metcalf +2 more
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Proliferations of Langerhans cells can be histologically divided into cytologically benign Langerhans cell proliferations, which include the clinical syndromes of Langerhans cell histiocytosis, and cytologically malignant Langerhans cell sarcoma. We report a Langerhans cell sarcoma in a 33-year-old male that arose on the posterior thigh with subsequent
John S. Metcalf +2 more
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Neuropeptides and Langerhans cells
Experimental Dermatology, 1998Abstract: The immune system and nervous system are intimately related. In addition to neuroendocrine mechanisms, neuropeptides have a variety of effects on immune cells and are responsible at least in part for neurogenic inflammation. The presence of neuropeptides in the skin has been well documented. The influence of neuropeptides on Langerhans cells
Richard D. Granstein, R. W. Lambert
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Current Opinion in Hematology, 1998
The term histiocytosis identifies a group of disorders characterized by localized or generalized reactive or neoplastic proliferation of cells similar, if not identical, to cells of the mononuclear phagocyte and dendritic cell systems. In Langerhans cell histiocytosis (LCH), the proliferating cell is the Langerhans cell, and the morphologic and ...
Raymond R. Tubbs, Kevin M. Herzog
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The term histiocytosis identifies a group of disorders characterized by localized or generalized reactive or neoplastic proliferation of cells similar, if not identical, to cells of the mononuclear phagocyte and dendritic cell systems. In Langerhans cell histiocytosis (LCH), the proliferating cell is the Langerhans cell, and the morphologic and ...
Raymond R. Tubbs, Kevin M. Herzog
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Archives of Disease in Childhood, 2009
Langerhans cell histiocytosis is a rare disease. Depending on which organs are involved, the disease may prove rapidly fatal, develop a chronic reactivating but therapy-responsive pattern or resolve spontaneously. Understanding of the pathology of the disease is progressing rapidly, and while clinical trials of standard chemotherapy agents continue, it
Kevin Windebank, Vasanta Nanduri
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Langerhans cell histiocytosis is a rare disease. Depending on which organs are involved, the disease may prove rapidly fatal, develop a chronic reactivating but therapy-responsive pattern or resolve spontaneously. Understanding of the pathology of the disease is progressing rapidly, and while clinical trials of standard chemotherapy agents continue, it
Kevin Windebank, Vasanta Nanduri
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