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Immunology & Cell Biology, 2010
Langerhans cells (LCs) are the resident dendritic cells (DCs) of epidermis in human mucosal stratified squamous epithelium and the skin. A phenotypically similar DC has recently been discovered as a minor population in the murine dermis. In epidermis, LCs function as sentinel antigen‐presenting cells that can capture invading viruses such as herpes ...
Najla Nasr +8 more
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Langerhans cells (LCs) are the resident dendritic cells (DCs) of epidermis in human mucosal stratified squamous epithelium and the skin. A phenotypically similar DC has recently been discovered as a minor population in the murine dermis. In epidermis, LCs function as sentinel antigen‐presenting cells that can capture invading viruses such as herpes ...
Najla Nasr +8 more
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Archives of Disease in Childhood, 2009
Langerhans cell histiocytosis is a rare disease. Depending on which organs are involved, the disease may prove rapidly fatal, develop a chronic reactivating but therapy-responsive pattern or resolve spontaneously. Understanding of the pathology of the disease is progressing rapidly, and while clinical trials of standard chemotherapy agents continue, it
Kevin Windebank, Vasanta Nanduri
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Langerhans cell histiocytosis is a rare disease. Depending on which organs are involved, the disease may prove rapidly fatal, develop a chronic reactivating but therapy-responsive pattern or resolve spontaneously. Understanding of the pathology of the disease is progressing rapidly, and while clinical trials of standard chemotherapy agents continue, it
Kevin Windebank, Vasanta Nanduri
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Journal of Cutaneous Medicine and Surgery, 2012
Background: The cutaneous presentation of Langerhans cell histiocytosis (LCH) is very rare and can be highly variable among individuals, which can often lead to a delay in diagnosis. Objective: To discuss a case report and literature review of important clinical indicators, histology, diagnosis, evaluation, and treatment guidelines.
Clayton Schiltz +2 more
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Background: The cutaneous presentation of Langerhans cell histiocytosis (LCH) is very rare and can be highly variable among individuals, which can often lead to a delay in diagnosis. Objective: To discuss a case report and literature review of important clinical indicators, histology, diagnosis, evaluation, and treatment guidelines.
Clayton Schiltz +2 more
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2008
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by accumulation of clonal CD1a-positive immature dendritic cells (LCH cells) accompanied by infiltration of various inflammatory cells such as eosinophils, lymphocytes, macrophages, and osteoclast-like multinuclear giant cells.
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Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by accumulation of clonal CD1a-positive immature dendritic cells (LCH cells) accompanied by infiltration of various inflammatory cells such as eosinophils, lymphocytes, macrophages, and osteoclast-like multinuclear giant cells.
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Langerhans’ Cell Histiocytosis
Orthopedic Clinics of North America, 1996Langerhans' Cell Histiocytosis, formerly known as Histiocytosis X, and its related syndromes (i.e., eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease) are briefly reviewed. The biology, clinical manifestations, and treatment options of the localized, single form and the disseminated, multisystem form are also discussed.
Maria C. Velez-Yanguas, Raj Warrier
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Journal of the American Academy of Dermatology, 2001
From the Department of Radiology, Division of Neuroradiology,a and the Department of Dermatology,b Indiana University Medical Center; and the Department of Oral Surgery Medicine and Pathology, Indiana University School of Dentistry.c Reprint requests: Ginat W. Mirowski, DMD, MD, Department of Dermatology, 550 N University Blvd, Suite 3240, Indianapolis,
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From the Department of Radiology, Division of Neuroradiology,a and the Department of Dermatology,b Indiana University Medical Center; and the Department of Oral Surgery Medicine and Pathology, Indiana University School of Dentistry.c Reprint requests: Ginat W. Mirowski, DMD, MD, Department of Dermatology, 550 N University Blvd, Suite 3240, Indianapolis,
Ginat W. Mirowski +2 more
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Current Opinion in Hematology, 1998
The term histiocytosis identifies a group of disorders characterized by localized or generalized reactive or neoplastic proliferation of cells similar, if not identical, to cells of the mononuclear phagocyte and dendritic cell systems. In Langerhans cell histiocytosis (LCH), the proliferating cell is the Langerhans cell, and the morphologic and ...
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The term histiocytosis identifies a group of disorders characterized by localized or generalized reactive or neoplastic proliferation of cells similar, if not identical, to cells of the mononuclear phagocyte and dendritic cell systems. In Langerhans cell histiocytosis (LCH), the proliferating cell is the Langerhans cell, and the morphologic and ...
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Childhood Langerhans cell histiocytosis: a disease with many faces
World Journal of Pediatrics, 2019A. Leung, J. Lam, K. Leong
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The immunobiology of Langerhans cells
Immunology Today, 1981Interest in the biology of Langerhans cells has recently been stimulated by observations, reviewed here by Peter Friedmann, that they are active members o f the immune system.
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Dermatologic Clinics, 2007
Langerhans cells (LC) are a subtype of dendritic cells, which reside in the epidermis. LCs are antigen-presenting cells that originate in bone marrow and enter the epidermis through blood vessels. LCs exhibit a variety of antigen receptors that are able to respond to a wide range of antigens.
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Langerhans cells (LC) are a subtype of dendritic cells, which reside in the epidermis. LCs are antigen-presenting cells that originate in bone marrow and enter the epidermis through blood vessels. LCs exhibit a variety of antigen receptors that are able to respond to a wide range of antigens.
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