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Langerhans cell histiocytosis

Current Opinion in Hematology, 1998
The term histiocytosis identifies a group of disorders characterized by localized or generalized reactive or neoplastic proliferation of cells similar, if not identical, to cells of the mononuclear phagocyte and dendritic cell systems. In Langerhans cell histiocytosis (LCH), the proliferating cell is the Langerhans cell, and the morphologic and ...
K M, Herzog, R R, Tubbs
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Langerhans cell histiocytosis

Archives of Disease in Childhood, 2009
Langerhans cell histiocytosis is a rare disease. Depending on which organs are involved, the disease may prove rapidly fatal, develop a chronic reactivating but therapy-responsive pattern or resolve spontaneously. Understanding of the pathology of the disease is progressing rapidly, and while clinical trials of standard chemotherapy agents continue, it
K, Windebank, V, Nanduri
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Langerhans cell histiocytosis

Skeletal Radiology, 2006
Langerhans cell histiocytosis (LCH) is a complex disease entity comprised of three distinct clinical syndromes that demonstrate indistinguishable histology. These syndromes are: eosinophilic granuloma, which is predominantly osseous or pulmonary; Hand-Schûller-Christian's disease, which involves multiple organ systems and, most typically, the skull ...
Kevin Bradford, Hoover   +2 more
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Langerhans' cells histiocytosis.

International journal of pediatric otorhinolaryngology, 1999
Langerhans cell histiocytosis (LCH) is a rare disorder of unknown cause, characterized by the proliferation of histiocytic cells in various tissues and organs. The role of the otolaryngologist is important in the early and accurate evaluation, staging and diagnosis of LCH, because it may mimic more common diseases such as otitis externa and acute ...
SELLARI FRANCESCHINI, STEFANO   +5 more
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The immunobiology of Langerhans cells

Immunology Today, 1981
Interest in the biology of Langerhans cells has recently been stimulated by observations, reviewed here by Peter Friedmann, that they are active members o f the immune system.
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Langerhans’ Cell Histiocytosis

Orthopedic Clinics of North America, 1996
Langerhans' Cell Histiocytosis, formerly known as Histiocytosis X, and its related syndromes (i.e., eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease) are briefly reviewed. The biology, clinical manifestations, and treatment options of the localized, single form and the disseminated, multisystem form are also discussed.
M C, Velez-Yanguas, R P, Warrier
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Langerhans Cell Receptors

Dermatologic Clinics, 2007
Langerhans cells (LC) are a subtype of dendritic cells, which reside in the epidermis. LCs are antigen-presenting cells that originate in bone marrow and enter the epidermis through blood vessels. LCs exhibit a variety of antigen receptors that are able to respond to a wide range of antigens.
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Langerhans cell histiocytosis

Australasian Journal of Dermatology, 2001
SUMMARYLangerhans cell histiocytosis is a rare condition that can affect any organ of the body. Patients of all ages may present to the dermatologist and it is important to make the diagnosis as quickly as possible, because time from presentation to diagnosis is of prognostic importance in adults with the disease.
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Langerhans Cell Histiocytosis

New England Journal of Medicine, 1987
Nearly a century has passed since Alfred Hand reported a case of "polyuria and tuberculosis,"1 later considered to be the first case of the Hand-Schul1er–Christian syndrome.
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