Results 71 to 80 of about 10,558,900 (341)

Nodal Langerhans cell neoplasm: detailing the diagnostic quandaries

Autopsy and Case Reports, 2022
Langerhans cells, found in the supra-basal region of the mucous membranes in the epidermis of the skin, in lymph nodes and thymus, function as antigen-presenting cells within the histiocyte system.
Zachariah Chowdhury, Juhi Varshney, Anil Singh, Satvik Khaddar   +3 more
doaj  

Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8+ T Cell Clones

Arthritis &Rheumatology, EarlyView.
Objective Psoriatic arthritis (PsA) is an HLA class I–associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T cell phenotype and clonality.
Lucy E. Durham, Frances Humby, Nora Ng, Roman Laddach, Elizabeth H. Gray, Sarah E. Ryan, Kathryn J. A. Steel, Rosie Ross, Giovanni A. M. Povoleri, Rosamond Nuamah, Kathy Fung, Athul Menon Kallayil, Pawan Dhami, Bruce W. Kirkham, Leonie S. Taams   +14 more
wiley   +1 more source

Langerhans Cell Histiocytosis in a Child with Unifocal Mandibular Lesion and Diabetes Insipidus: A Case Report

مجله دانشکده پزشکی اصفهان, 2010
Background: Patients with Langerhans cell histiocytosis are at particularly high risk for central diabetes insipi-dus (CDI) due to hypothalamic-pituitary disease. Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the
Zahra Alian, Mahin Hashemipour, Mohammad Hassan Moaddab   +2 more
doaj  

Isolated Langerhans Histiocytosis in Thyroid: Thyroidectomy or Chemotherapy? [PDF]

Journal of Clinical and Diagnostic Research, 2015
Langerhans cell histiocytosis (LCH) is a rare disorder of mononuclear phagocytic system whose clinical presentation varies from the localised involvement of a single bone to a widely disseminated disease.
Anoop Attakkil, Vandana Thorawade, Mohan Jagade, Rajesh Kar, Kartik Parelkar   +4 more
doaj   +1 more source

Epidermal Interferon kappa drives cutaneous lupus‐like lesions, photosensitivity and systemic autoimmunity in vivo

Arthritis &Rheumatology, Accepted Article.
Objective Keratinocyte‐derived interferon kappa (IFN‐κ) is chronically overexpressed in human non‐lesional systemic lupus erythematosus (SLE) skin. Recent evidence suggests that epidermal signals instruct the immune system in SLE, but whether epidermal IFN‐κ alone is sufficient to drive lupus phenotypes has not been investigated.
Benjamin Klein, Deborah J. Colesa, Yiqing Gao, Patrick A. O'Brien, Lin Zhang, Lori Lowe, Kelsey E. McNeely, Nguyen Thi Kim Nguyen, Svenja Henning, Mehrnaz Gharaee‐Kermani, Jeffrey B. Hodgin, Jacob W. S. Martens, Johann E. Gudjonsson, Celine C. Berthier, J. Michelle Kahlenberg   +14 more
wiley   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Elderly male patient presenting with jaundice and cholangitis brings an unexpected histopathological finding, case report

Heliyon
In this report, we present a case of the first-time manifestation of Langerhans cell histiocytosis in the biliary tract of a 79-year-old male patient. Cholangiocarcinoma was the suspected diagnosis, based on the patient's painless jaundice.
Gergana Nenova, Dietrich A. Ruess, Sophia Chikhladze, Heiko Becker, Sylvia Timme-Bronsert, Uwe Wittel   +5 more
doaj   +1 more source

Langerhans Cell Histiocytosis of the Thyroid with Multiple Cervical Lymph Node Involvement Accompanying Metastatic Thyroid Papillary Carcinoma

Case Reports in Pathology, 2014
A 37-year-old male case was admitted with goiter. Ultrasonography of thyroid showed a 5 cm cystic nodule in the left lobe with a 1.5 cm solid component. Fine needle aspiration biopsy revealed atypia of undetermined significance or follicular lesion.
A. Bahar Ceyran, Serkan Şenol, Barış Bayraktar, Şeyma Özkanlı, Z. Leyla Cinel, Abdullah Aydın   +5 more
doaj   +1 more source

Phenolic Compounds From Myrcia tijucensis: Insights Into Antioxidant and Antidiabetic Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT The genus Myrcia from the Myrtaceae family contains species with therapeutic properties, such as reducing glycemia and oxidative stress. This study investigated the effects of the hydroalcoholic extract of Myrcia tijucensis in an animal model of Type 1 diabetes induced by alloxan.
Nathielli Nayara Pauleti, Brenda Wiggers, Ana Luiza de Moraes G. Boaventura, Ana Carolina Dutra, Luiz Guilherme de Alcantara Grilo, Jan Pereira Wotmeyer, Camila Jeriane Paganelli, Camila Panini, Rafaela Beatriz Cunha, Michele Debiasi Alberton, Luciano Vitali, Gustavo Amadeu Micke, Daniela Delwing‐de Lima, Débora Delwing‐Dal Magro   +13 more
wiley   +1 more source

Profiling a Neo‐Antigen‐Driven Immune Response in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Study of the KLH Challenge Model

Clinical Pharmacology &Therapeutics, EarlyView.
Novel compounds targeting the adaptive immune system are commonly initially investigated in healthy volunteers (HV). HV frequently lack constitutively expressed drug‐target engagement biomarkers, complicating the evaluation of pharmacological activity. The keyhole limpet hemocyanin (KLH) neo‐antigen challenge elicits a controlled immune response in HV ...
Micha N. Ronner, Hendrika W. Grievink, Mahdi Saghari, Michelle Osse, Thierry P.P. van den Bosch, Jeffrey Damman, Marieke L. de Kam, Jacobus Burggraaf, Naomi B. Klarenbeek, Manon A. A. Jansen, Matthijs Moerland   +10 more
wiley   +1 more source