Results 61 to 70 of about 12,127,574 (275)
Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart
Arthritis &Rheumatology, EarlyView.Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald +9 more
wiley +1 more source
Nodal Langerhans cell neoplasm: detailing the diagnostic quandaries
Autopsy and Case Reports, 2022 Langerhans cells, found in the supra-basal region of the mucous membranes in the epidermis of the skin, in lymph nodes and thymus, function as antigen-presenting cells within the histiocyte system.
Zachariah Chowdhury +3 more
doaj
Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks
Journal of Experimental Medicine, 2013 Langerhans cell homeostasis and differentiation depends on PU.1, the latter via regulation of TGF-β–dependent binding of PU.1 to the regulatory elements of RUNX3.
Michael Chopin +7 more
semanticscholar +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects. [PDF]
PLoS ONE, 2016 Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non ...
Susanne M Reinartz +5 more
doaj +1 more source
Langerhans cells: an update [PDF]
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2014 SummaryLangerhans cells belong to the family of dendritic cells, professional antigen‐presenting cells, and populate the skin and epithelia of mammals. It was the extensive investigation of this particular dendritic cell subpopulation in earlier days, which contributed crucially to the current understanding of the regulation of antigen processing and ...
openaire +3 more sources
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
iMeta, EarlyView.Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni +26 more
wiley +1 more source
Indeterminate Cell Histiocytosis: A Case Report
Kaohsiung Journal of Medical Sciences, 2004 Indeterminate cell histiocytosis is a rare neoplasm composed of cells with mixed characteristics of Langerhans cells and non-Langerhans cells. An otherwise healthy, 36-year-old woman presented with asymptomatic generalized papules and nodules that had ...
Chun-Hua Wang, Gwo-Shing Chen
doaj +1 more source