Results 181 to 190 of about 39,048 (228)

Multiple Transplantations of Islets of Langerhans

European Surgical Research, 1977
In 6 diabetic rats about 1,000 isolated islets of Langerhans were transplanted into the liver with little effect on the uninsulinism and hyperglycemia. Subsequently, a second transplantation resulted in a decrease of blood sugar to normal and in a reversal of the loss in body weight. Finally, in animals who had reversed to diabetes again, a third islet
K D, Rumpf, D, Löhlein, , Pichlmayr
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Langerhans islet preparation in cell transplantation

Transfusion Science, 1997
Islet cell transplantation is potentially one of the best techniques for the almost perfect symptomatic treatment of Type 1 diabetes mellitus. Thanks to the considerable progress achieved in isolating and purifying human islet cells, highly encouraging results have recently been reported.
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GABA production in rat islets of Langerhans

Diabetes, 1993
Homogenates of pancreatic islets catalyzed breakdown of L-glutamate to GABA with a rate of 0.24 ± 0.04 nmol · min−1 · mg−1 protein at 37°C. The formation of GABA was stimulated by addition of pyridoxal phosphate in the range 0.05–1 microM (0.97 ± 0.02 nmol · min−1 · mg protein-1 at a saturating cofactor concentration), which indicates that the process ...
M, Michalik, J, Nelson, M, Erecińska
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[Islet of Langerhans transplantation].

Annales de chirurgie, 1996
Islet of Langerhans transplantation is considered to be the ideal treatment for type I insulin-dependent diabetes. The permanent and adapted insulin secretion obtained by this method ensures prevention or even regression of the degenerative lesions which now constitute the severity of this frequent disease.
K, Boudjema, E, Alexandre
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[Islets of Langerhans transplantation].

Nephrologie & therapeutique, 2007
The objective of future therapy of type 1 diabetes is to prevent the development of the chronic complications of the disease, while reducing the constraints imposed by treatment and eliminating the risk of hypoglycaemia. In other words, the aim is to ensure automatic glycaemic control like the normal pancreas. We can then talk about a cure for diabetes.
Alfred, Penfornis, Stéphanie, Kury-Paulin   +1 more
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WHY ARE THE ISLETS OF LANGERHANS ?

The Lancet, 1969
Abstract In the course of evolution, endocrine pancreatic tissue has moved away from its origin in the gut and become distributed throughout the exocrine pancreas as the islets of Langerhans. It is suggested that this is not an evolutionary accident, but that high local concentrations of islet hormones play a significant role in the metabolism of the ...
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Microtubule interactions in islets of Langerhans.

Hormone and metabolic research. Supplement series, 1980
Morphologic and functional studies have implicated islet microtubules in the transport of the B-cell secretory product form the endoplasmic reticulum to the peripheral pool of secretory vesicles. The participation of the microtubular apparatus in the insulin release mechanism appears to be mediated through an increased rate of tubulin synthesis and of ...
Pipeleers, D G, Harnie, N, Heylen, L, Wauters, G   +3 more
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Langerhans islets transplantation

1998
Da
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Transplantation of islets of Langerhans

Journal of Hepato-Biliary-Pancreatic Surgery, 1994
The present study attempts to evaluate the possibility of using cryopreserved pancreatic islets in rats. Insulin-releasing activity was studied for the purpose of clarifying the function of cryopreserved islets. Cryopreserved pancreatic islets were also transplanted into the portal veins of recipient rats.
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Engineering islets from stem cells for advanced therapies of diabetes

Nature Reviews Drug Discovery, 2021
Matthias Meier, Heiko Lickert
exaly