Results 221 to 230 of about 8,360 (233)

Langerin‐expressing dendritic cells in gut‐associated lymphoid tissues

Immunological Reviews, 2010
Summary:  Dendritic cells (DCs) are key regulators of the immune system. They act as professional antigen‐presenting cells and are capable of activating naive T cells and stimulating the growth and differentiation of B cells. According to their molecular expression, DCs can be divided into several subsets with different functions.
Sun-Young Chang, Mi-Na Kweon
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Kinetic and Structural Studies of Interactions between Glycosaminoglycans and Langerin

Biochemistry, 2016
Langerin, a C-type lectin, is expressed in Langerhans cells. It was reported that langerin binds sulfated glycans, which is an important initial step for its role in blocking human immunodeficiency virus (HIV) transmission by capturing HIV pathogens and mediating their internalization into Birbeck granules for their elimination.
Fuming Zhang, Quanhong Li, Xinyue Liu, Emily Zhang, Robert J. Linhardt, Chelsea Kao, Jing Zhao   +6 more
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Langerin is a natural barrier to HIV-1 transmission by Langerhans cells

Nature Medicine, 2007
Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN). However, the epithelial Langerhans cells (LCs) are the first DC subset to encounter HIV-1.
de Witte, Lot, Nabatov, Alexey, Pion, Marjorie, Fluitsma, Donna, de Jong, Marein A W P, de Gruijl, Tanja, Piguet, Vincent, van Kooyk, Yvette, Geijtenbeek, Teunis B H   +8 more
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New aspects of langerin dendritic cells in patients with COPD

Airway Cell Biology and Immunopathology, 2017
Background: Alveolar antigen uptake has remained poorly investigated in human lungs and it is unclear to what extent dendritic cell (DC) subsets are altered in the alveolar parenchyma of patients with COPD. Objectives: To assess the distribution and marker profile of DCs in distal lungs of patients with COPD.
Claes-Göran Löfdahl, Abraham B. Roos, Michiko Mori, Martin R. Stämpfli, Jonas S. Erjefält, Premkumar Siddhuraj   +5 more
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¹⁹F NMR-Guided Design of Glycomimetic Langerin Ligands

ACS Chemical Biology, 2016
C-type lectin receptors (CLRs) play a pivotal role in pathogen defense and immune homeostasis. Langerin, a CLR predominantly expressed on Langerhans cells, represents a potential target receptor for the development of anti-infectives or immunomodulatory therapies.
Wamhoff, E., Hanske, J., Schnirch, L., Aretz, J., Grube, M., Varón Silva, D., Rademacher, C.   +6 more
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Langerin-expressing and CD83-expressing cells in oral lichen planus lesions

Acta Odontologica Scandinavica, 2007
Dendritic Langerhans cells (LCs) have been attributed a role in the pathogenesis of lichen planus as autoantigen-presenting cells initiating expansion of autoreactive T cells. Langerin and CD83, which are cell molecules expressed on LCs, are associated with antigen presentation.
Christina Eklund, Mats Wallström, Göran Zellin, Bengt Magnusson, Jenny Gustafson, Bengt Hasséus   +5 more
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Gene Polymorphisms of CD207 (Langerin) Are Associated With End-Stage Renal Disease

Transplantation Proceedings, 2016
The CD207 molecule, also known as langerin, is known to be the first immunologic barrier expressed on Langerhans cells, which are the immature dendritic cells of the epidermis and mucosa. Inflammation could be a causal factor in the progression of chronic kidney disease.
Sun Woo Kang, Yeong Hoon Kim, Bong-Seok Kim   +2 more
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Dectin-1 and langerin

Pilz-Beta-Glukane aktivieren die Immunantwort über verschiedene Rezeptoren, darunter C-Typ-Lektin-Rezeptoren (CLRs). Eine besondere Rolle spielt dabei Dectin-1. Frühere Studien deuteten darauf hin, dass der Dectin-1-Signalweg, der zur Interleukinproduktion führt, nur durch Hefepartikel aktiviert werden konnte, indem eine Immunsynapse gebildet wird. Die
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The Origin and Function of Langerin (CD207) Expressing Cells in Mice and Humans

Blood, 2012
Abstract Abstract SCI-7 The current paradigm suggests that Langerhans cell histiocytosis (LCH) results from an accumulation of epidermal dendritic cells also called Langerhans cells. This concept is based on phenotypic and ultrastructural observations showing that LCH lesions are infiltrated by CD1a+langerin+ cells, two ...
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Langerin

2008
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