Results 151 to 160 of about 83,346 (245)

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

Langevin dynamics with a tilted periodic potential

, 2013
We study a Langevin equation for a particle moving in a periodic potential in the presence of viscosity $\gamma$ and subject to a further external field $\alpha$.
G.A. Pavliotis, Gioia Carinci, H. Landau, H. Risken, H. Risken, H.A. Kramers, J.M. Perez-Mato, J.M. Perez-Mato, M. Hairer, M.B. Marcus, M.I. Freidlin, N. Berglund, R.L. Stratonovich, R.L. Stratonovich, Stephan Luckhaus   +14 more
core   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Modeling the Intermediate Flow Regime in Flow‐Compensated Intravoxel Incoherent Motion MRI

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3476-3487, June 2026.
ABSTRACT Purpose The intravoxel incoherent motion (IVIM) model is commonly used to separate the effects of motion related to diffusion and blood microcirculation (perfusion) on the MR signal. Depending on the encoding time (T), it is possible to probe the different temporal regimes of blood motion, which resemble a ballistic flow at short T and a ...
Louise Rosenqvist, Mikael Montelius, Isabella M. Björkman‐Burtscher, Elina Petersson, Maria Ljungberg, Oscar Jalnefjord   +5 more
wiley   +1 more source

An Overview of Artificial Intelligence and Machine Learning Approaches for Building Energy Analysis, Characterization, Control, and Grid Support Services Provision

WIREs Energy and Environment, Volume 15, Issue 2, June 2026.
Artificial Intelligence and Machine Learning Approaches used in Building Energy Analysis, Control, and Provision of Grid Support Services. ABSTRACT Increasing penetrations of variable renewable energy sources like wind and solar photovoltaic (PV) systems are challenging power system stability worldwide.
Jack S. Bryant, Hangxin Li, Nawanjana Maheepala, Xiaoyu Lin, Mingkun Dai, Binglong Han, Robin Guan, Lasantha Meegahapola, Shengwei Wang, Dilan Robert, Liuping Wang, Fu Xiao   +11 more
wiley   +1 more source

Asymmetry of the Ferroelectric Phase Transition in BaTiO3

Advanced Materials, Volume 38, Issue 25, 4 May 2026.
Phase transitions are typically assumed to behave identically in forward and reverse. This work shows that in the ferroelectric material barium titanate this is not true: heating drives an abrupt, first‐order jump, while cooling gives a smooth, continuous change.
Asaf Hershkovitz, Elangovan Hemaprabha, Rajesh Mandal, Pravin Kavle, Jamil Tanus, Maya Barzilay, Ching‐Che Lin, David Spirito, Semën Gorfman, Bo Wang, Ignacio J. Villar‐García, Neus Domingo, Long‐Qing Chen, Lane W. Martin, Yachin Ivry   +14 more
wiley   +1 more source

Deformation‐Induced Formation of Stray Grains in Additive Manufacturing of Single Crystals

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Stray grain formation severely limits the additive manufacturing of single‐crystal alloys. By integrating in situ synchrotron techniques, ex situ characterization, and multi‐scale multi‐physics modeling, the authors reveal that stray grains originate from dislocations at the solid‐liquid interface, rather than thermal supercooling in conventional ...
Dongsheng Zhang, Zixu Guo, Yuxiao Li, Lu Wang, Yu Wu, Darui Sun, Wentao Yan, Yuanyuan Guo, Han Wang, Wei Liu, Ye Tao, Bingbing Zhang   +11 more
wiley   +1 more source

Ligand‐driven modulation of chaperone–cochaperone networks shapes proteostasis outcomes

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Protein homeostasis depends on a delicate interplay between folding and degradation, orchestrated by molecular chaperones. Among them, Hsp90 is a central hub, regulating nearly 10% of the proteome through ATP‐driven conformational cycles and selective interactions with cochaperones.
Andrea Magni, Giorgio Bonollo, Gauthier Trèves, Francesco Frigerio, Fabrizio Cinquini, Silvia Pavoni, A. Sofia F. Oliveira, Adrian J. Mulholland, Stefano A. Serapian, Giorgio Colombo   +9 more
wiley   +1 more source

Hydrophobic interactions of a substrate with L193 on the flexible substrate‐binding loop contribute to 3α‐hydroxysteroid dehydrogenase/carbonyl reductase catalytic efficiency

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Flexible loops within enzyme active sites are central to substrate binding, transition‐state stabilization, and catalytic turnover. Hydrophobic interactions modulate ligand recognition and influence protein function. Here, we interrogated loop‐mediated hydrophobic contributions to catalysis in 3α‐hydroxysteroid dehydrogenase/carbonyl reductase
Yan‐Liang Chen, Yun‐Hao Chou, Hwei‐Jen Lee, Tzu‐Pin Wang, Chi‐Ching Hwang   +4 more
wiley   +1 more source

Fluctuating β‐Sheet Secondary Structure in DS119 Explains the Small Effects of Backbone N‐Amination on Thermal Stability

Journal of Peptide Science, Volume 32, Issue 5, May 2026.
Residues with backbone N‐amination have been introduced into a region of parallel β‐sheet secondary structure. Contrary to predictions, the N‐amination of Trp9 or Phe33 did not give an increase in the thermal stability of DS119. MD simulations suggest this is due to the highly fluctuating nature of the β‐sheet region. ABSTRACT The miniprotein DS119 has
Yushi Qiao, Syrah K. Starnes, Jožica Dolenc, Juan R. Del Valle, Lorna J. Smith   +4 more
wiley   +1 more source