Results 61 to 70 of about 6,114,820 (273)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Language Evolution and Music Evolution

Together with language, music is perhaps the most distinctive behavioral trait of our species. Different hypotheses have been proposed to explain why only humans speak and why only they perform music and, if both abilities are evolutionary related, how and why they eventually diverged. Human linguisticality and musicality are certainly biologically and
Antonio Benítez-Burraco, Aleksey Nikolsky   +1 more
openaire   +1 more source

On the Evolution of Programming Languages

CoRR, 2020
This paper attempts to connects the evolution of computer languages with the evolution of life, where the later has been dictated by \emph{theory of evolution of species}, and tries to give supportive evidence that the new languages are more robust than the previous, carry-over the mixed features of older languages, such that strong features gets added
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Singular-plural verb stem alternation: uncovering global and local drivers of typological variation

Linguistic Typology
In this paper, we present a comparative concept for singular-plural verb stem alternation (Sg-Pl alternation) and a systematic global survey of its presence as well as its syntactic and semantic attributes, with a denser sample in the Americas.
Inman David, Vuillermet Marine
doaj   +1 more source

Innateness and culture in the evolution of language [PDF]

Proceedings of the National Academy of Sciences, 2006
Human language arises from biological evolution, individual learning, and cultural transmission, but the interaction of these three processes has not been widely studied. We set out a formal framework for analyzing cultural transmission, which allows us to investigate how innate learning biases are related to universal properties of language.
Simon, Kirby, Mike, Dowman, Thomas L, Griffiths   +2 more
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Non-adjacent dependency processing (or lack thereof) in bonobos: an artificial grammar experiment

Royal Society Open Science
A key feature of language is our capacity to process syntactic relationships between words, whether they are directly sequential (‘adjacent dependencies’) or separated by other words (‘non-adjacent dependencies’).
Maël Leroux, Nicole J. Lahiff, Chiara Zulberti, Amanda Epping, Calle Uerling, Jared P. Taglialatela, Jutta L. Mueller, Stuart K. Watson, Simon W. Townsend   +8 more
doaj   +1 more source

The puzzle of language evolution [PDF]

Kognitionswissenschaft, 1999
The work in Brussels has been financed by a GOA grant of the Belgian government.
openaire   +4 more sources