Results 81 to 90 of about 195,033 (294)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Clues to language evolution from a massive dataset with typology, phonology and vocabulary from many languages

, 2018
1. Introduction A major component in the evolution of language is the evolution of the human language capacity, whatever biological endowments humans have that make us language-ready.
Johansson, Sverker, Sverker Johansson
core   +1 more source

Linguistic pitch is hierarchically encoded in the right ventral stream

Communications Biology
A challenge for speech perception research is to explain how listeners transform speech sounds into meaning. Using MEG and complementary analytical methods, we expose the neural dynamics that generate meaningful linguistic units (e.g., sentence type ...
Chantal Oderbolz, Joan Orpella, Martin Meyer   +2 more
doaj   +1 more source

Language Evolution and Music Evolution

Together with language, music is perhaps the most distinctive behavioral trait of our species. Different hypotheses have been proposed to explain why only humans speak and why only they perform music and, if both abilities are evolutionary related, how and why they eventually diverged. Human linguisticality and musicality are certainly biologically and
Antonio Benítez-Burraco, Aleksey Nikolsky   +1 more
openaire   +1 more source

The puzzle of language evolution [PDF]

Kognitionswissenschaft, 1999
The work in Brussels has been financed by a GOA grant of the Belgian government.
openaire   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Polysemy and metaphorical extension in an artificial language learning experiment

Language and Cognition
This study investigates the emergence of metaphorical meanings in abstract visual symbols within an ‘alien language’ artificial language learning game. Findings reveal that participants extend concrete meanings to abstract meanings based on metaphorical ...
Michael Pleyer, Elizabeth Qing Zhang, Marek Placiński   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The evolution of language and languages

, 1998
Human languages, such as French, Cantonese or American Sign Language, are socio- cultural entities. Knowledge of them (`competence') is acquired by exposure to the ap- propriate environment. Languages are maintained and transmitted by acts of speaking and writing; and this is also the means by which languages evolve.
openaire   +2 more sources